ADAMTS4
ADAMTS4蛋白全称为整合素样金属蛋白酶与血小板反应蛋白基序4，常被称为Aggrecanase-1或ADMP-1。该蛋白在维持细胞外基质动态平衡中起关键作用，能够特异性分解软骨组织中的核心成分aggrecan，这种特性使其成为关节退行性疾病的重要研究靶点。在骨关节炎和类风湿性关节炎患者体内，其异常活跃的酶切活性会加速软骨基质破坏，导致关节结构塌陷和功能丧失。ADAMTS4在肿瘤微环境中同样扮演着特殊角色，可能通过重塑细胞外基质促进癌细胞侵袭转移，特别是在乳腺癌和胶质瘤中观察到其表达水平与疾病进展密切相关。
针对ADAMTS4的药物开发主要聚焦于选择性抑制剂研究，已有多个小分子化合物进入临床前试验阶段，通过阻断其酶活性来减缓软骨退化进程。其中部分黄酮类衍生物在动物模型中显示出保护关节软骨的效果，而基于单克隆抗体的靶向疗法也取得突破性进展。值得关注的是，某些已上市的抗炎药物被发现具有间接调控该蛋白活性的潜能，这为老药新用开辟了新方向。目前相关研究正在探索其在神经退行性疾病中的应用价值，特别是阿尔茨海默病中淀粉样斑块的形成可能与ADAMTS4介导的蛋白水解过程存在关联。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ADAMTS4 Antibody (CSB-PA001311LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA001311LA01HU at dilution of 1:100
Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: ADAMTS4 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 91 kDa
Observed band size: 91 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001311LA01HU at dilution of 1:100
IHC image of CSB-PA001311LA01HU diluted at 1:250 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human ADAM metallopeptidase with thrombospondin type 1 motif4,ADAMTS4 ELISA Kit (CSB-E11848h)
验证数据
货号：CSB-E11848h
规格：96T/48T
灵敏度：3.125 ng/ml
检测范围：12.5 ng/ml - 800 ng/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ADAMTS4 Antibodies
ADAMTS4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA001311LA01HU | ADAMTS4 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA001311LB01HU | ADAMTS4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA001311LC01HU | ADAMTS4 Antibody, FITC conjugated | Human | |
| CSB-PA001311LD01HU | ADAMTS4 Antibody, Biotin conjugated | Human | ELISA |
ADAMTS4 Proteins
ADAMTS4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001311HU CSB-EP001311HU CSB-BP001311HU CSB-MP001311HU CSB-EP001311HU-B |
Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001311HU1 | Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), partial | E.coli |
ADAMTS4 ELISA Kit
ADAMTS4 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E11848h | Human ADAM metallopeptidase with thrombospondin type 1 motif4,ADAMTS4 ELISA Kit | serum, plasma, tissue homogenates | 3.125 ng/ml |
