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ADAMTS4

ADAMTS4蛋白全称为整合素样金属蛋白酶与血小板反应蛋白基序4,常被称为Aggrecanase-1或ADMP-1。该蛋白在维持细胞外基质动态平衡中起关键作用,能够特异性分解软骨组织中的核心成分aggrecan,这种特性使其成为关节退行性疾病的重要研究靶点。在骨关节炎和类风湿性关节炎患者体内,其异常活跃的酶切活性会加速软骨基质破坏,导致关节结构塌陷和功能丧失。ADAMTS4在肿瘤微环境中同样扮演着特殊角色,可能通过重塑细胞外基质促进癌细胞侵袭转移,特别是在乳腺癌和胶质瘤中观察到其表达水平与疾病进展密切相关。
针对ADAMTS4的药物开发主要聚焦于选择性抑制剂研究,已有多个小分子化合物进入临床前试验阶段,通过阻断其酶活性来减缓软骨退化进程。其中部分黄酮类衍生物在动物模型中显示出保护关节软骨的效果,而基于单克隆抗体的靶向疗法也取得突破性进展。值得关注的是,某些已上市的抗炎药物被发现具有间接调控该蛋白活性的潜能,这为老药新用开辟了新方向。目前相关研究正在探索其在神经退行性疾病中的应用价值,特别是阿尔茨海默病中淀粉样斑块的形成可能与ADAMTS4介导的蛋白水解过程存在关联。

热销产品

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), partial (CSB-EP001311HU1)

验证数据

CSB-EP001311HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ADAMTS4 Antibody (CSB-PA001311LA01HU)

验证数据

CSB-PA001311LA01HU

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA001311LA01HU at dilution of 1:100

CSB-PA001311LA01HU

Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: ADAMTS4 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 91 kDa
Observed band size: 91 kDa

CSB-PA001311LA01HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001311LA01HU at dilution of 1:100

CSB-PA001311LA01HU

IHC image of CSB-PA001311LA01HU diluted at 1:250 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human ADAM metallopeptidase with thrombospondin type 1 motif4,ADAMTS4 ELISA Kit (CSB-E11848h)

验证数据

CSB-E11848h 标准曲线

货号:CSB-E11848h

规格:96T/48T

灵敏度:3.125 ng/ml

检测范围:12.5 ng/ml - 800 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ADAMTS4 Antibodies

ADAMTS4 for Homo sapiens (Human)

ADAMTS4 Proteins

ADAMTS4 Proteins for Homo sapiens (Human)

ADAMTS4 ELISA Kit

ADAMTS4 ELISA Kit for Homo sapiens (Human)