ADAMTS13
ADAMTS13，即血管性血友病因子裂解酶。别名VWFCP、C9orf8、vWF-CP、ADAM-TS13等。ADAMTS13主要在肝星状细胞中表达，是一种金属蛋白酶，其主要功能是特异性切割具有促血栓作用的大分子血管性血友病因子（VWF）多聚体。ADAMTS13通过作用于VWF-A2结构域内1605位酪氨酸和1606位蛋氨酸之间的肽键，通过对VWF多聚体的切割使之具有合适的大小，防止VWF诱导的血小板过度聚集和血栓形成，从而发挥维持出凝血平衡的作用。近年来，ADAMTS13在血液病、肝病、心脑血管病和感染性疾病的发病、治疗与预后中的作用越来越受到重视，其活性降低会导致血液中UL-VWFM的蓄积，引起异常血小板聚集和广泛微血管血栓形成。
热销产品
ADAMTS13 Antibody (CSB-PA001301LA01HU)
验证数据
IHC image of CSB-PA001301LA01HU diluted at 1:400 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
ADAMTS13 Antibodies
ADAMTS13 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA001301LA01HU | ADAMTS13 Antibody | Human | ELISA, IHC |
| CSB-PA001301LB01HU | ADAMTS13 Antibody, HRP conjugated | Human | ELISA |
ADAMTS13 Proteins
ADAMTS13 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP748481HU CSB-EP748481HU CSB-BP748481HU CSB-MP748481HU CSB-EP748481HU-B |
Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADAMTS13 ELISA Kit
ADAMTS13 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E13487h | Human von Willebrand Factor cleaving protease,ADAMTS-13/vWF-cp ELISA Kit |
