ACSL4
ACSL4，即长链酰基辅酶A合成酶4，别名ACS4、FACL4、LACS4、MRX63、MRX68、XLID63。它是由人类基因组中的ACSL4基因编码的蛋白，该基因定位于X染色体的Xq22.3~23区域。ACSL4在多种组织中表达，尤其在肾上腺、阑尾等组织中表达量较高。其作用机制是通过催化游离长链脂肪酸转化为酰基辅酶A酯，参与脂质生物合成和脂肪酸降解，优先利用花生四烯酸作为底物。ACSL4在调节脂质代谢、炎症反应、胰岛素分泌、骨骼肌蛋白代谢以及细胞死亡方式如铁死亡中发挥重要作用。ACSL4的异常表达与多种疾病相关，包括非酒精性脂肪肝、癌症、缺血性中风和急性肾损伤。ACSL4被认为是多种疾病治疗的潜在靶点。
热销产品
ACSL4 Antibody (CSB-PA060488EA01HU)
验证数据
Western blot
All lanes: ACSL4 antibody at 2µg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 80, 75 kDa
Observed band size: 80 kDa
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA060488EA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA060488EA01HU at dilution of 1:100
ACSL4 Antibodies
ACSL4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA060488EA01HU | ACSL4 Antibody | Human | ELISA, WB, IHC |
| CSB-PA289963 | ACSL4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA283716 | ACSL4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
ACSL4 Proteins
ACSL4 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001193RA CSB-EP001193RA CSB-BP001193RA CSB-MP001193RA CSB-EP001193RA-B |
Recombinant Rat Long-chain-fatty-acid--CoA ligase 4 (Acsl4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACSL4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001193HU1 CSB-EP001193HU1 CSB-BP001193HU1 CSB-MP001193HU1 CSB-EP001193HU1-B |
Recombinant Human Long-chain-fatty-acid--CoA ligase 4 (ACSL4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001193HU | Recombinant Human Long-chain-fatty-acid--CoA ligase 4 (ACSL4) | in vitro E.coli expression system |
ACSL4 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP879427MO CSB-BP879427MO CSB-MP879427MO CSB-EP879427MO-B |
Recombinant Mouse Long-chain-fatty-acid--CoA ligase 4 (Acsl4), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP879427MO | Recombinant Mouse Long-chain-fatty-acid--CoA ligase 4 (Acsl4), partial | E.coli |
