Rat Retinol binding protein 4,RBP-4 ELISA Kit
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中文名称：大鼠视黄醇结合蛋白4(RBP-4)酶联免疫试剂盒
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货号：CSB-E09424r
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规格：96T/48T
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价格：￥3900/￥2500
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其他：
产品详情
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产品描述：大鼠视黄醇结合蛋白4(RBP-4)酶联免疫试剂盒（CSB-E09424r）为竞争法ELISA试剂盒，定量检测样本中的RBP4含量。RBP4，全称视黄醇结合蛋白4，是一种在血浆中运输视黄醇的重要蛋白，由肝细胞合成，并在多种体液中分布。它在视黄醇的运输和分布过程中发挥关键作用，与TTR和STRA6等蛋白相互作用，参与调节视黄醇的细胞膜运输和防止肾小球滤过损失。RBP4的研究涉及其在代谢、心血管疾病和胰岛素抵抗等病理过程中的作用机制。适用于代谢疾病机制研究、营养学实验或药物干预模型中RBP - 4动态变化的分析，为肥胖、糖尿病等科研领域提供可靠的数据支持，仅限科学研究使用。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
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别名：Rbp4 ELISA Kit; Retinol-binding protein 4 ELISA Kit; Plasma retinol-binding protein ELISA Kit; PRBP ELISA Kit; RBP ELISA Kit
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缩写：
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Uniprot No.：
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种属：Rattus norvegicus (Rat)
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样本类型：
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检测范围：
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灵敏度：
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Signal Transduction
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测定原理：quantitative
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测定方法：Competitive
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数据处理：
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货期：3-5 working days
引用文献
- Augmentation of RBP4/STRA6 signaling leads to insulin resistance and inflammation and the plausible therapeutic role of vildagliptin and metformin K Gokulakrishnan,Molecular Biology Reports,2021
- The effect of moderate endurance training on gastrocnemius retinol-binding protein 4 and insulin resistance in streptozotocin-induced diabetic rats YousefiMohammad-Reza.et al,Interventional Medicine and Applied Science,2017
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靶点详情
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最新研究进展：RBP4是一种在维生素A代谢中起关键作用的蛋白质，但它也与一些代谢性疾病如肥胖、糖尿病和代谢综合征等有关。一些最新的研究表明，RBP4可能作为这些疾病的潜在生物标志物和治疗靶点，有望为相关疾病的治疗提供新的思路和策略。
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功能：Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
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基因功能参考文献：
- RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
- plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
- Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
- Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
- Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
- RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
- Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839
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亚细胞定位：Secreted.
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蛋白家族：Calycin superfamily, Lipocalin family
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组织特异性：Detected in blood plasma (at protein level).
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数据库链接：
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