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Human amyloid beta peptide 1-40,Aβ1-40 ELISA Kit

文献引用 (11) 说明书下载

中文名称：

人β淀粉样蛋白1-40(Aβ1-40)酶联免疫试剂盒
货号：

CSB-E08299h
规格：

96T/48T
价格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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产品描述：

人β淀粉样蛋白1-40(Aβ1-40)酶联免疫试剂盒（CSB-E08299h）为双抗夹心法ELISA试剂盒，定量检测血清、组织匀浆、脑脊液（CSF）样本中的Aβ1-40含量。Aβ1-40是β-淀粉样蛋白的一种，在阿尔茨海默病研究中备受关注。其在大脑中异常聚集形成淀粉样斑块，是该病的病理特征之一。研究机制主要聚焦于探究其生成、清除过程的失衡，以及它对神经元毒性作用等方面，以寻找治疗AD的新靶点。试剂盒检测范围为125 pg/mL-8000 pg/mL，可广泛应用于神经退行性疾病机制研究、药物开发中淀粉样蛋白调控效果评估、以及脑脊液生物标志物谱分析等科研领域，为探索Aβ1 - 40在病理过程中的分子作用提供可靠工具。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

amyloid beta peptide 1-40,Aβ1-40,amyloid β peptide 1-40
缩写：

Aβ1-40
种属：

Homo sapiens (Human)
样本类型：

serum, tissue homogenates, cerebrospinal fluid (CSF)
检测范围：

125 pg/mL-8000 pg/mL
灵敏度：

31.25 pg/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Neuroscience
测定原理：

quantitative
测定方法：

Sandwich

精密度：

Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.

线性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human Aβ1-40 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
		Sample		Serum(n=4)
1:1		Average %		87
		Range %		80-92
1:2		Average %		99
		Range %		91-105
1:4		Average %		95
		Range %		92-98
1:8		Average %		103
		Range %		96-110

回收率：

The recovery of human Aβ1-40 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type		Average % Recovery		Range
Serum (n=5)		98		89-100

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
8000	2.846	2.687	2.767	2.610
4000	2.237	2.089	2.163	2.006
2000	1.679	1.612	1.646	1.489
1000	1.246	1.211	1.229	1.072
500	0.736	0.697	0.717	0.560
250	0.512	0.498	0.505	0.348
125	0.303	0.296	0.300	0.143
0	0.160	0.154	0.157

数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

引用文献

GNG5 is a novel regulator of Aβ42 production in Alzheimer's disease C Li, Y Yang, S Luo, W Qiu, X Wang, W Ge,Cell Death & Disease,2024
Oab-14 Alleviates Mitochondrial Impairment Through the Sirt3-Dependent Mechanism in App/Ps1 Transgenic Mice and N2a/App Cells N Zheng, R Cao, D Liu, P Liu, X Zhao, S Zhang,Available at SSRN 5013649,/
Targeting blood brain barrier—Remote ischemic conditioning alleviates cognitive impairment in female APP/PS1 rats Y Ma,CNS neuroscience & therapeutics,2024
The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology X Wang,Nature communications,2024
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization D Yao,Translational psychiatry,2023
Extracellular Vesicles Play a Central Role in Cerebral Venous Disease‐Associated Brain Atrophy JY Wang,Advanced science,2023
Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model M Hu,Nature communications,2023
Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway X Wang,Biomedicine & pharmacotherapy,2023
Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin C Qian,Research Square,2021
Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology Jiang X, et al,Journal of Ethnopharmacology,2019
Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease Ya-Ru Wen.et al,NRR,2018

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■ 常见问题解答

Q:

We are interested in this kit.Could you let me know the information about the following ?
Do you have the information of capture antibody coated on the plate and biotinylated detection antibody in the kit?

A:

Thanks for your inquiry.
Capture antibody:mouse monoclonal antibody;Detection antibody:goat polyclonal antibody.

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本司产品仅用于科研，不用于临床诊断和治疗

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九游平台-九游(中国) | 米兰体育-米兰体育（中国） | 开云手机在线登陆入口 | 江南官方体育网页版 | 开云网页版 | 开云官方在线入口 | 开云电子体育 | 开云官方链接 | 江南网页版页面登录 |