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  4. Recombinant Rat ATP-binding cassette sub-family B member 8, mitochondrial (Abcb8)

Recombinant Rat ATP-binding cassette sub-family B member 8, mitochondrial (Abcb8)

  • 中文名称：
    Recombinant Rat ATP-binding cassette sub-family B member 8, mitochondrial(Abcb8)
  • 货号：
    CSB-CF732841RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Abcb8
  • Uniprot No.：
    Q5RKI8
  • 别名：
    Abcb8; Mitosur; Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    39-714
  • 氨基酸序列
    SSCLLRAVAQLRSQLRAHLPRSPPASHRSTSAWCWVGGTLVVPAVLWQHPRFCLIALCEA KGSPPAQPTRARELRFKWKLFWHFLHPHLLALGLAIVLALGAALVNVQIPLLLGQLVEIV AKYTREHVGSFVSESRRLSIQLLLLYGVQGLLTFGYLVLLSHMGERMAMDMRKALFSSLL RQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSSTQVIGSLMTLSILSPRLTL MLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGSVRTVRAFAMEKREEER YQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGDLMSFLV ASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMSLSPVIPLTGGYSIPSKDLRGSITFQN VSFSYPCRPGFNVLKNFTLKLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVTLDGH DLRTLDPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTAARKANAHEFISS FPDGYSTVVGERGTTLSGGQKQRLAIARALIKRPTVLILDEATSALDAESERIVQEALDR ASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLQKGGLYAELIRRQALDASL PSAPPAEKPEDHRSCQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Abcb8 Proteins

靶点详情

  • 功能：
    ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes.
  • 基因功能参考文献：
    1. These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins. PMID: 22375032
    2. In the testis, rat abcb8 was expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes). PMID: 16390497
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
  • 组织特异性：
    Strong expression is found in the heart, brain and testis. In the testis, expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes). Also expressed in the lung, liver, intestine and k
  • 数据库链接：

    KEGG: rno:362302

    STRING: 10116.ENSRNOP00000012222

    UniGene: Rn.79339

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