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  4. Recombinant Mouse Pro-neuregulin-3, membrane-bound isoform (Nrg3)

Recombinant Mouse Pro-neuregulin-3, membrane-bound isoform (Nrg3)

  • 中文名称：
    小鼠Nrg3重组蛋白
  • 货号：
    CSB-CF016079MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Nrg3
  • Uniprot No.：
    O35181
  • 别名：
    Nrg3; Pro-neuregulin-3, membrane-bound isoform; Pro-NRG3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-713
  • 氨基酸序列
    MSEGAAGASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPPTVLSTTAPFFSSSTPGSRPPMPGAPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAAAASSSSPSSTSSTTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEHLKESQNGKNYSLKASSTKSESLMKSHVHLQNYSKADRHPVTALEKIMESSFSAPQSFPEVTSPDRGSQPIKHHSPGQRSGMLHRNTFRRAPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYVSNGLRTQQNASINMQLPSRETNPYFNSLDQKDLVGYLSPRANSVPIIPSMGLEETCMQMPGISDVKSIKWCKNSYSADIVNASMPVSDCLLEEQQEVKILLETVQEQIRILTDARRSEDFELASMETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSVLTK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Nrg3 Proteins

靶点详情

  • 功能：
    Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors.
  • 基因功能参考文献：
    1. Studied the physiologic role of neuregulin3 (NRG3) in regulating glutamatergic transmission in pyramidal neurons. Found NRG3 regulates the SNARE-complex assembly, and NRG3 knockout causes display behavior deficits related to mental illness. PMID: 29463705
    2. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits. PMID: 28147272
    3. This study demonistrated that Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. PMID: 24703509
    4. NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia. PMID: 21837948
    5. a Neuregulin3 signaling pathway is involved in specification of mammary gland morphogenesis PMID: 16140987
    6. used positional cloning to narrow the interval containing scaramanga (ska) to a 75.6-kb interval containing the distal part of the Neuregulin3 (Nrg3) gene PMID: 16140987

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  • 亚细胞定位：
    [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-3]: Secreted.
  • 蛋白家族：
    Neuregulin family
  • 组织特异性：
    Expressed in sympathetic, motor, and sensory neurons.
  • 数据库链接：

    KEGG: mmu:18183

    STRING: 10090.ENSMUSP00000136884

    UniGene: Mm.258705

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