Recombinant Mouse ER lumen protein retaining receptor 1 (Kdelr1)

in vitro E.coli expression system

中文名称：

小鼠Kdelr1重组蛋白
货号：

CSB-CF860796MO
规格：
来源：

in vitro E.coli expression system
其他：

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基因名：

Kdelr1
Uniprot No.：

Q99JH8
别名：

Kdelr1; ER lumen protein-retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1
种属：

Mus musculus (Mouse)
蛋白长度：

full length protein
表达区域：

1-212
氨基酸序列

MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYN TCMKVVYIACSFTTVWMIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEILW TFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIA IVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

N-terminal 10xHis-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

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功能：

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
基因功能参考文献：
1. In a mouse line having nonfunctional KDELR1, polyclonal naive T cells show excessive integrated stress responses, which are rescued by strong TCR-mediated signaling PMID: 26489882
2. regulates naive T-cell homeostasis by controlling integrated stress responses PMID: 26081938
3. present a recessive mouse missense allele of the prototypical mammalian KDEL receptor, KDEL ER protein retention receptor 1 (KDELR1). Kdelr1 homozygous mutants were mildly lymphopenic, as were mice with a CRISPR/Cas9-engineered frameshift allele PMID: 26438836
4. dilated cardiomyopathy found in the mutant KDEL receptor transgenic mice is associated with ER stress PMID: 15340063
亚细胞定位：

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein.
蛋白家族：

ERD2 family
数据库链接：

KEGG: mmu:68137

STRING: 10090.ENSMUSP00000002855

UniGene: Mm.298433

Recombinant Mouse ER lumen protein retaining receptor 1 (Kdelr1)

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