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  4. Recombinant Mouse Claudin-6(Cldn6)-VLPs

Recombinant Mouse Claudin-6(Cldn6)-VLPs

  • 中文名称：
    Recombinant Mouse Claudin-6(Cldn6)-VLPs
  • 货号：
    CSB-MP3347MO
  • 规格：
    ￥4000
  • 图片：
    • CSB-MP3347MO is detected by Mouse anti-6*His monoclonal antibody.
    • The purity of VLPs was greater than 95% as determined by SEC-HPLC
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SEC-HPLC.
  • 生物活性：
    Not Test
  • 基因名：
    Cldn6
  • Uniprot No.：
    Q9Z262
  • 别名：
    Skullin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    Mammalian cell
  • 分子量：
    24.8 kDa
  • 表达区域：
    1-219aa
  • 氨基酸序列
    MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVTLLIVLLGLLVYLAGAKCTTCVEDRNSKSRLVLISGIIFVISGVLTLIPVCWTAHSIIQDFYNPLVADAQKRELGASLYLGWAASGLLLLGGGLLCCACSSGGTQGPRHYMACYSTSVPHSRGPSEYPTKNYV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 10xHis-tagged
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能参考文献：
    1. Cldn6 was markedly decreased in the lungs of mice exposed to acute tobacco sm PMID: 27982694
    2. These data reveal captivating information suggesting a role for Cldn6 in lungs exposed to tobacco smoke and suggest that further research is necessary in order to fully explain roles for tight junctional components such as Cldn6 PMID: 27763528
    3. Over-expression of Claudin 6 during embryogenesis delays lung morphogenesis. PMID: 26198145
    4. Cldn6 is expressed by pulmonary epithelium during lung organogenesis. PMID: 24970044
    5. The Inv-Cldn6-CDelta206 transgenic mice displayed a developmental delay in epidermal permeability barrier formation, as shown by the expression of keratins and Cldns, and by X-Gal penetration assays. PMID: 20106878
    6. the normally robust injury response mechanism of the epidermis is lost in the aging Involucrin-Cldn6-CDelta196 transgenic epidermis PMID: 19915705
    7. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. PMID: 11923212
    8. Cldn6 plays a role in the differentiation processes of the epidermis and hair follicle PMID: 15908185
    9. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 ce PMID: 16306693
    10. developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13 PMID: 16774906
    11. Results demonstrate that the overexpression of a tail truncation mutant of claudin 6 (Cldn6) mislocalizes Cldn6 and other Cldn proteins to the cytoplasm and triggers a postnatal increase in proliferation and aberrant differentiation of the epidermis. PMID: 16847338
    12. Tight junctions containing claudin 6 are essential for blastocyst formation in preimplantation mouse embryos PMID: 17980358
    13. A lineage analysis of the fate of Cldn6-expressing embryonic endoderm cells is relevant to the development of the pancreas, lung, and liver. PMID: 18213590
    14. Expression analysis in mice has shown that Claudin-6 is one of the few genes that allows for the targeting of the definitive endoderm throughout the entire anterior-posterior axis, before and after gut tube patterning. PMID: 18213590

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 组织特异性：
    Expressed mostly in embryonic tissues.
  • 数据库链接：

    KEGG: mmu:54419

    STRING: 10090.ENSMUSP00000024699

    UniGene: Mm.86421

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