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  4. Recombinant Mouse Calcium uniporter protein, mitochondrial (Mcu)

Recombinant Mouse Calcium uniporter protein, mitochondrial (Mcu)

  • 中文名称：
    小鼠Mcu重组蛋白
  • 货号：
    CSB-CF668882MO
  • 规格：
    ￥9720
  • 图片：
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF668882MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Mcu.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF668882MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Mcu.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Mcu
  • Uniprot No.：
    Q3UMR5
  • 别名：
    Mcu; Calcium uniporter protein, mitochondrial
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    37.7 kDa
  • 表达区域：
    50-350aa
  • 氨基酸序列
    AHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Mcu Proteins

靶点详情

  • 功能：
    Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. Participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
  • 基因功能参考文献：
    1. the endothelial barrier was preserved in respiratory epithelium isolated from MCU-/- mice after exposure to IL-13. In the ovalbumin-model of allergic airway disease, MCU deficiency resulted in decreased apoptosis within the large airway epithelial cells. Concordantly, expression of the tight junction protein ZO-1 was preserved, indicative of maintenance of epithelial barrier function PMID: 29225050
    2. Results suggest that inhibition of MCU attenuates Abeta-induced mcroglial apoptosis, and that it does so through modulation of reactive oxygen species-mediated endoplasmic reticulum stress. Understanding the apparent links between endoplasmic reticulum stress, oxidative stress and MCU could lead to the development of therapeutic strategies targeting Abeta-mediated microglial death. PMID: 28939404
    3. These data indicate that Ca(2+) uptake via mitochondrial uniporter contributes to palmitic acid-induced apoptosis in mouse podocytes. PMID: 28181698
    4. MCU expression returned to physiological levels in visceral adipose tissue of patients after weight loss by bariatric surgery. Altered mitochondrial calcium flux in fat cells may play a role in obesity and diabetes and may be associated with the differential metabolic profiles of visceral and subcutaneous adipose tissue. PMID: 28790027
    5. Regulation of mitochondrial Ca(2+) suggests that MCU may play a pivotal role in the development of fibrosis and could potentially be a therapeutic target for pulmonary fibrosis. PMID: 28351840
    6. Reveal a distinct functional role for Cys-97 in mitochondrial reactive oxygen species sensing and regulation of MCU activity. PMID: 28262504
    7. The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria. PMID: 27642048
    8. Data show that the serine/threonine kinase LKB1 regulates mitochondrial calcium uniporter (MCU)-expression, mitochondria-dependent Ca2+ clearance, and thereby, presynaptic release properties. PMID: 27429220
    9. the Mcu-regulating Micu gene family profile differs substantially between neurons and astrocytes, while expression of Mcu itself is markedly different between CA3 and CA1 regions in the adult hippocampus. PMID: 26828201
    10. Absence of MCU expression does not affect basal cardiac function at either 12 or 20months of age in knockout mice. PMID: 26057074
    11. MCU is required to match energetics with contractile demand during stress. Deletion of Mcu protects against myocardial IR injury. PMID: 26119731
    12. Mice lacking MCU in the heart show no pathology. MCU selectively mediates acute mitochondria Ca2+ loading to augment ATP synthesis. PMID: 26119742
    13. MCU is necessary for complete physiological heart rate acceleration PMID: 25603276
    14. MCU-VDAC1 complex regulates mitochondrial Ca(2+) uptake and oxidative stress-induced apoptosis PMID: 25753332
    15. Chromatin immunoprecipitation and promoter reporter analyses revealed that the Ca2+ -regulated transcription factor CREB (cyclic adenosine monophosphate response element-binding protein) directly bound the MCU promoter and stimulated expression. PMID: 25737585
    16. chronic myocardial MCU inhibition leads to previously unanticipated compensatory changes. PMID: 26153425
    17. Tetrodotoxin-sensitive mitochondrial Ca(2+) influx was largely blocked by knockdown of MCU expression. PMID: 24719357
    18. Characterization of MCU deficient mice indicates that acute alterations in mitochondrial matrix calcium can regulate mammalian physiology. PMID: 24212091
    19. Exogenously expressed Mcu is mitochondrially localized and increases mitochondrial Ca(2+) levels following NMDA receptor activation, leading to increased mitochondrial membrane depolarization and excitotoxic cell death. PMID: 23774321
    20. The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. MCU has the fine control of the mitochondrial calcium homeostasis. PMID: 23900286
    21. Data show that the recently-identified mitochondrial Ca(2+) uniporter, MCU, is required for depolarisation-induced mitochondrial Ca(2+) increases, and for a sustained increase in cytosolic ATP/ADP ratio. PMID: 22829870
    22. genomic, physiological, biochemical and pharmacological data firmly establish MCU as an essential component of the mitochondrial Ca(2+) uniporter PMID: 21685886
    23. data demonstrate that the 40-kDa protein identified is the channel responsible for ruthenium-red-sensitive mitochondrial Ca(2+) uptake, thus providing a molecular basis for this process of utmost physiological and pathological relevance PMID: 21685888
    24. Includes expression analysis of the mouse Ccdc109a (MCU) gene. PMID: 21685888
    25. In vivo silencing of CCDC109a (MCU) in mouse liver abolishes mitochondrial calcium uptake without perturbing gross liver anatomy, mitochondrial oxygen consumption or membrane potential. PMID: 21685886
    26. Ccdc109a was identified in this large-scale proteomics analysis as a mitochondrial protein broadly expressed in many mouse tissues. The human protein was also confirmed to localize to mitochondria. PMID: 18614015

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MCU (TC 1.A.77) family
  • 组织特异性：
    Detected in heart muscle (at protein level). Expressed in skeletal muscle, heart, kidney, liver, brain, lung, white fat and spleen.
  • 数据库链接：

    KEGG: mmu:215999

    STRING: 10090.ENSMUSP00000020312

    UniGene: Mm.296470

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