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  4. Recombinant Human Metalloreductase STEAP2 (STEAP2)-VLPs

Recombinant Human Metalloreductase STEAP2 (STEAP2)-VLPs

  • 中文名称：
    人STEAP2重组蛋白
  • 货号：
    CSB-MP854119HU
  • 规格：
  • 其他：

产品详情

  • 基因名：
    STEAP2
  • Uniprot No.：
    Q8NFT2
  • 别名：
    STEAP2; PCANAP1; STAMP1; UNQ6507/PRO23203; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
  • 种属：
    Homo sapiens (Human)
  • 来源：
    Mammalian cell
  • 表达区域：
    1-490aa
  • 氨基酸序列
    MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it’s possible to develop.
  • 产品提供形式：
    Lyophilized powder
    Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
  • 缓冲液：
    Lyophilized from PBS, 6% Trehalose, pH 7.4
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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STEAP2 antibodies

STEAP2 Proteins

靶点详情

  • 功能：
    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
  • 基因功能参考文献：
    1. Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
    2. Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    4. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
    5. STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
    6. Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
    7. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
    8. The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065

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  • 亚细胞定位：
    Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    STEAP family
  • 组织特异性：
    Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
  • 数据库链接：

    HGNC: 17885

    OMIM: 605094

    KEGG: hsa:261729

    STRING: 9606.ENSP00000287908

    UniGene: Hs.489051

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