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  4. Recombinant Human ATP synthase subunit C lysine N-methyltransferase (ATPSCKMT)-VLPs

Recombinant Human ATP synthase subunit C lysine N-methyltransferase (ATPSCKMT)-VLPs

  • 中文名称：
    Recombinant Human ATP synthase subunit C lysine N-methyltransferase (ATPSCKMT)-VLPs
  • 货号：
    CSB-MP761288HU
  • 规格：
  • 其他：

产品详情

  • 基因名：
    ATPSCKMT
  • Uniprot No.：
    Q6P4H8
  • 别名：
    Protein N-lysine methyltransferase FAM173B;hFAM173B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    Mammalian cell
  • 表达区域：
    1-233aa
  • 氨基酸序列
    MEGGGGIPLETLKEESQSRHVLPASFEVNSLQKSNWGFLLTGLVGGTLVAVYAVATPFVTPALRKVCLPFVPATTKQIENVVKMLRCRRGSLVDIGSGDGRIVIAAAKKGFTAVGYELNPWLVWYSRYRAWREGVHGSAKFYISDLWKVTFSQYSNVVIFGVPQMMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA：
    Please contact us to get it.

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ATPSCKMT Proteins

靶点详情

  • 功能：
    Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia.
  • 基因功能参考文献：
    1. Genetic alteration of JS-2 was found to be related to location, pathological subtypes and staging of colorectal cancer. PMID: 21802380
  • 亚细胞定位：
    Mitochondrion membrane; Single-pass membrane protein.
  • 蛋白家族：
    FAM173 family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 27029

    KEGG: hsa:134145

    UniGene: Hs.481569

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