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  4. Recombinant Xenopus laevis Neurogenic locus notch protein homolog (notch1), partial

Recombinant Xenopus laevis Neurogenic locus notch protein homolog (notch1), partial

  • 中文名称：
    有爪蟾蜍notch1重组蛋白
  • 货号：
    CSB-YP322025XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍notch1重组蛋白
  • 货号：
    CSB-EP322025XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍notch1重组蛋白
  • 货号：
    CSB-EP322025XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍notch1重组蛋白
  • 货号：
    CSB-BP322025XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍notch1重组蛋白
  • 货号：
    CSB-MP322025XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    notch1
  • Uniprot No.：
    P21783
  • 别名：
    notch1; xotch; Neurogenic locus notch homolog protein 1; Notch 1; xOTCH) [Cleaved into: Notch 1 extracellular truncation; NEXT); Notch 1 intracellular domain; NICD)]
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
  • 基因功能参考文献：
    1. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3 PMID: 21610033
    2. Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline. PMID: 21276789
    3. Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 gene or the constitutively active form of Notch (IC). PMID: 21194527
    4. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. PMID: 20547764
    5. results suggest that a cell-to-cell interaction via the Notch/Su(H) pathway has a significant role in the PGC migration by regulating cell motility PMID: 20151992
    6. the process of delimiting the three germ layers requires Notch signaling. PMID: 20079726
    7. the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis PMID: 15172688
    8. Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells. PMID: 15300513
    9. Notch controls smad2 nuclear localization and the competence of ectodermal cells for activin A in Xenopus embryos PMID: 15817224
    10. Notch signaling has a role during the prepatterning of the cardiac mesoderm PMID: 19580804

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Notch 1 intracellular domain]: Nucleus.
  • 蛋白家族：
    NOTCH family
  • 数据库链接：

    KEGG: xla:394367

    UniGene: Xl.1057

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