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  4. Recombinant Xenopus laevis Focal adhesion kinase 1 (ptk2), partial

Recombinant Xenopus laevis Focal adhesion kinase 1 (ptk2), partial

  • 中文名称：
    有爪蟾蜍ptk2重组蛋白
  • 货号：
    CSB-YP835520XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍ptk2重组蛋白
  • 货号：
    CSB-EP835520XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍ptk2重组蛋白
  • 货号：
    CSB-EP835520XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍ptk2重组蛋白
  • 货号：
    CSB-BP835520XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍ptk2重组蛋白
  • 货号：
    CSB-MP835520XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ptk2
  • Uniprot No.：
    Q91738
  • 别名：
    ptk2; fak1Focal adhesion kinase 1; FADK 1; EC 2.7.10.2; Protein-tyrosine kinase 2; pp125FAK
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly.
  • 基因功能参考文献：
    1. evidence that despite the fact that FAK is in the active, open conformation at CAs, its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells. PMID: 27895123
    2. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex. PMID: 25341507
    3. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm. PMID: 25127991
    4. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development PMID: 24048589
    5. These data suggest an important role for the FERM domain in the activation of FAK. PMID: 22880041
    6. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF, while phosphorylation at Y925 controls the rate of point contact turnover. PMID: 21940449
    7. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis. PMID: 20572259
    8. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins. PMID: 19890008

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium basal body. Note=Constituent of focal adhesions.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, FAK subfamily
  • 数据库链接：

    KEGG: xla:399286

    UniGene: Xl.6819

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