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  4. Recombinant Xenopus laevis Cytoplasmic polyadenylation element-binding protein 1-A (cpeb1-a), partial

Recombinant Xenopus laevis Cytoplasmic polyadenylation element-binding protein 1-A (cpeb1-a), partial

  • 中文名称：
    Recombinant Xenopus laevis Cytoplasmic polyadenylation element-binding protein 1-A(cpeb1-a) ,partial
  • 货号：
    CSB-YP856243XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Xenopus laevis Cytoplasmic polyadenylation element-binding protein 1-A(cpeb1-a) ,partial
  • 货号：
    CSB-EP856243XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Xenopus laevis Cytoplasmic polyadenylation element-binding protein 1-A(cpeb1-a) ,partial
  • 货号：
    CSB-EP856243XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Xenopus laevis Cytoplasmic polyadenylation element-binding protein 1-A(cpeb1-a) ,partial
  • 货号：
    CSB-BP856243XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Xenopus laevis Cytoplasmic polyadenylation element-binding protein 1-A(cpeb1-a) ,partial
  • 货号：
    CSB-MP856243XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    cpeb1-a
  • Uniprot No.：
    Q91572
  • 别名：
    cpeb1-a; cpebCytoplasmic polyadenylation element-binding protein 1-A; CPE-BP1-A; CPE-binding protein 1-A; CPEB-1-A; 58 kDa CPE-binding protein
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In the absence of phosphorylation and in association with tacc3/maskin, also acts as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Requires zinc for RNA binding. Involved in the cell cycle progression from S phase into M phase.
  • 基因功能参考文献：
    1. Pin1 is an essential factor regulating CPEB degradation PMID: 23090969
    2. CPEB is not required for regulation of early class maternal mRNA translational activation in Xenopus oocytes PMID: 14752101
    3. XGef is involved in early CPEB activation with GTPase signaling PMID: 15635100
    4. These results demonstrate that a reversible Pum2 interaction controls RINGO/Spy mRNA translation and, as a result, CPEB-mediated cytoplasmic polyadenylation PMID: 16418484
    5. Xenopus Gef (XGef), a Rho-family guanine-exchange factor, influences the activating phosphorylation of CPEB. PMID: 17344432
    6. affects experience-dependent neuronal development and circuit formation in the visual system of Xenopus laevis PMID: 19074264
    7. Data show that CPEB1 mRNA transcripts are present at low levels in RGCs but, surprisingly, CPEB1 protein was not detected in eye or brain tissue, and CPEB1 loss-of-function does not affect chemotropic responses or pathfinding in vivo. PMID: 19254368

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Membrane. Note=During mitosis localizes with tacc3/maskin and CPE-containing mRNAs to both spindle poles. Membrane-associated. Colocalizes with members of the polyadenylation and translation complex factors (cpsf, aplp1, tacc3/maskin, aurka, etc.), including CPE-containing RNAs.
  • 蛋白家族：
    RRM CPEB family
  • 组织特异性：
    Expressed uniformly in growing oocytes (stage I to IV) and distributed at the animal pole in fully-grown oocytes (stages V and VI) (at protein level). During early oocyte maturation its expression remains constant and then declines drastically during late
  • 数据库链接：

    KEGG: xla:399289

    UniGene: Xl.984

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