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  4. Recombinant Xenopus laevis Alpha-ketoglutarate-dependent dioxygenase FTO (fto), partial

Recombinant Xenopus laevis Alpha-ketoglutarate-dependent dioxygenase FTO (fto), partial

  • 中文名称：
    有爪蟾蜍fto重组蛋白
  • 货号：
    CSB-YP718083XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍fto重组蛋白
  • 货号：
    CSB-EP718083XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍fto重组蛋白
  • 货号：
    CSB-EP718083XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍fto重组蛋白
  • 货号：
    CSB-BP718083XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍fto重组蛋白
  • 货号：
    CSB-MP718083XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    fto
  • Uniprot No.：
    Q68F54
  • 别名：
    ftoAlpha-ketoglutarate-dependent dioxygenase FTO; EC 1.14.11.-
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Partial
  • 表达区域：
    1-501
  • 氨基酸序列
    MKKRGVLCEE EKEVKKRKLL EQIGDGHLPY LSSKDDTFYD LWGSCYSKLT LLQAKHVPVD LHHTVQNAFL SLLRNGCLFQ DLVRLKGKDI ITPVSRILIG RPGYTYKYLN TRLFAVPWIN DELNTQYSTR NLLETYKAFS DLNDFLYSQT VNELQKLGKI HKDNFFQHSE YKEQIKSDQR PSTSNYENVK LHSMESFNVT LINYMDPQNM SFLKEEPYFG MGKMAVSWHH DENLVEQSTV AVYNYSYQES SNDVNGEDED PTRWHVGLKI AWDIETPGLL MPLSSGDCYL MLDDLNKTHQ HCVIAGCQPR FSSTHRVAES STGTLQYIKS QCNSALQNLH MNPDTGAADL KNLEPNVLGQ TEEIHNEVEF EWLRQFWFQG KRYNKCTTFW KEAMTELEIH WKQMETMTSL VLKAIENENL TVDEKCNILK NILPPLVERQ DLRHDWRERC RSKLAKMLPP DQVPCFYPYW NDDNKTMPLP FDLHNIISAL QKTLEENELK L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs.
  • 亚细胞定位：
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    Fto family
  • 数据库链接：

    KEGG: xla:447305

    UniGene: Xl.34271

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