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  4. Recombinant Uncharacterized protein F54F2.2, isoform a (F54F2.2/F54F2.3/F54F2.4), partial

Recombinant Uncharacterized protein F54F2.2, isoform a (F54F2.2/F54F2.3/F54F2.4), partial

  • 中文名称：
    秀丽隐杆线虫F54F2.2/F54F2.3/F54F2.4重组蛋白
  • 货号：
    CSB-YP335940CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫F54F2.2/F54F2.3/F54F2.4重组蛋白
  • 货号：
    CSB-EP335940CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫F54F2.2/F54F2.3/F54F2.4重组蛋白
  • 货号：
    CSB-EP335940CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫F54F2.2/F54F2.3/F54F2.4重组蛋白
  • 货号：
    CSB-BP335940CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫F54F2.2/F54F2.3/F54F2.4重组蛋白
  • 货号：
    CSB-MP335940CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    F54F2.2/F54F2.3/F54F2.4
  • Uniprot No.：
    P34447
  • 别名：
    zfp-1; F54F2.2Zinc finger protein zfp-1; Protein AF-10 homolog
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription. Recognizes and binds histone H3 methylated at 'Lys-4' (H3K4me) at the promoters of target genes. During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated gene expression. Thus, most likely via this mechanism, in response to stress, it confers a protective role against neuronal necrosis. Plays a role in Insulin/IGF-1-like signaling (IIS)- and diet restriction-mediated lifespan extension by controlling daf-16/FOXO and pha-4/FOXA recruitment to target promoters. May negatively regulate the expression of genes required for vulval development. May play a role in axon guidance in D-type motor neurons. May suppress sensitivity to RNAi.; Required for migration of HSN motor neurons during embryogenesis.
  • 基因功能参考文献：
    1. the coordinated activities of DAF-16, ZFP-1, and endogenous RNAi contribute to gene regulation during development to ensure proper neuronal positioning PMID: 24558261
    2. ZFP-1 localization peaks overlap with H3K4 methylation-enriched promoters of actively expressed genes genomewide and that H3K4 methylation is important for ZFP-1 localization to promoters in the embryo. PMID: 23263989
    3. We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant. PMID: 21980302
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 组织特异性：
    Isoform a: Expressed at high levels in maturing oocytes, but at low levels in the rest of the germ line (at protein level). Isoform a: Not expressed in the pharynx, germ line and tail. Isoform c: Not expressed in the germ line (at protein level). Isoform
  • 数据库链接：

    STRING: 6239.F54F2.2a.3

    UniGene: Cel.22669

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