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  4. Recombinant Sheep Estrogen receptor beta (ESR2), partial

Recombinant Sheep Estrogen receptor beta (ESR2), partial

  • 中文名称：
    绵羊ESR2重组蛋白
  • 货号：
    CSB-YP890595SH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    绵羊ESR2重组蛋白
  • 货号：
    CSB-EP890595SH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    绵羊ESR2重组蛋白
  • 货号：
    CSB-EP890595SH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    绵羊ESR2重组蛋白
  • 货号：
    CSB-BP890595SH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    绵羊ESR2重组蛋白
  • 货号：
    CSB-MP890595SH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ESR2
  • Uniprot No.：
    Q9TU15
  • 别名：
    ESR2; NR3A2Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2
  • 种属：
    Ovis aries (Sheep)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
  • 基因功能参考文献：
    1. In uterine artery endothelial cells: 1) eNOS phosphorylation changes occur via ER-alpha- and ER-beta-dependent mechanisms and 2) ER-alpha and ER-beta can both increase NO levels independently from each other. PMID: 27170438
    2. Numerous ERbeta-immunoreactive cells were located throughout the hypothalamus and, following dual-label immunocytochemistry, over 50% of the GnRH neurones were found to express immunoreactive ERbeta PMID: 15720473
    3. ERalpha and ERbeta mRNA and protein are expressed in UA endothelium with expression levels depending on the endocrine status of the animal. PMID: 15774511
    4. Moreover, the high expression of both 17beta-HSD type 12 and ERbeta in breast carcinoma cells may play a role in the development and/or progression of breast cancer. PMID: 16930994
    5. estrogen receptor 1 and 2(ESR1 and ESR2) mediate feedback of estradiol(E2) on secretion of LH PMID: 17429013
    6. The expression of ER-alpha and ER-beta in the brain and pituitary of fetal sheep are influenced by circulating estrogen concentrations and acutely regulated in response to cerebral hypoperfusion. PMID: 18160819
    7. Ontogeny of ERB and its co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation is reported. PMID: 18204852

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 数据库链接：

    KEGG: oas:443066

    UniGene: Oar.651

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