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  4. Recombinant Serine/threonine-protein kinase par-4 (par-4), partial

Recombinant Serine/threonine-protein kinase par-4 (par-4), partial

  • 中文名称：
    秀丽隐杆线虫par-4重组蛋白
  • 货号：
    CSB-YP867092CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫par-4重组蛋白
  • 货号：
    CSB-EP867092CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫par-4重组蛋白
  • 货号：
    CSB-EP867092CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫par-4重组蛋白
  • 货号：
    CSB-BP867092CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫par-4重组蛋白
  • 货号：
    CSB-MP867092CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    par-4
  • Uniprot No.：
    Q9GN62
  • 别名：
    par-4; Y59A8B.14; Serine/threonine-protein kinase par-4; EC 2.7.11.1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein stabilization. May regulate the integrity of the early embryonic cortex in a strd-1-dependent manner. Phosphorylates and regulates aak-2 in response to oxidative stress and during dauer development. May also play a role in motility, behavioral response, regulation of lifespan and dauer formation through this pathway. Required to establish germline stem cell (GSC) quiescence during dauer development. Acts downstream of unc-40 in dendrite outgrowth. May play a role in cell shedding during embryogenesis, probably by phosphorylating pig-1.
  • 基因功能参考文献：
    1. the regulation of the cytoskeleton and cell polarity may contribute significantly to the tumour suppressor function of LKB1/par-4. PMID: 29907081
    2. We report here that din-1S is required in parallel to par-4/LKB1 signaling within the gonad to establish cell cycle quiescence during the onset of the dauer stage. PMID: 27260305
    3. PAR-4/LKB1 impinges on myosin via two pathways, an anillin-dependent pathway that also responds to the cullin CUL-5 and an anillin-independent pathway involving the kinase PIG-1/MELK. PMID: 26416962
    4. Par-4 activates PIG-1 by phosphorylation of T169. PMID: 23267054
    5. the serine-threonine kinase PAR-4 (LKB1) was selectively required for the activity of the UNC-40 pathway in dendrite outgrowth. PMID: 21186357
    6. The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior PMID: 18408008

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  • 亚细胞定位：
    Cytoplasm, cell cortex.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, LKB1 subfamily
  • 组织特异性：
    Expressed in the gonads, oocytes and early embryos (at protein level).
  • 数据库链接：

    KEGG: cel:CELE_Y59A8B.14

    STRING: 6239.Y59A8B.14a

    UniGene: Cel.19519

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