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  4. Recombinant Schizosaccharomyces pombe Coiled-coil quantitatively-enriched protein 1 (ccq1), partial

Recombinant Schizosaccharomyces pombe Coiled-coil quantitatively-enriched protein 1 (ccq1), partial

  • 中文名称：
    Recombinant Schizosaccharomyces pombe Coiled-coil quantitatively-enriched protein 1(ccq1) ,partial
  • 货号：
    CSB-YP607405SXV
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Schizosaccharomyces pombe Coiled-coil quantitatively-enriched protein 1(ccq1) ,partial
  • 货号：
    CSB-EP607405SXV
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Schizosaccharomyces pombe Coiled-coil quantitatively-enriched protein 1(ccq1) ,partial
  • 货号：
    CSB-EP607405SXV-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Schizosaccharomyces pombe Coiled-coil quantitatively-enriched protein 1(ccq1) ,partial
  • 货号：
    CSB-BP607405SXV
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Schizosaccharomyces pombe Coiled-coil quantitatively-enriched protein 1(ccq1) ,partial
  • 货号：
    CSB-MP607405SXV
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ccq1
  • Uniprot No.：
    Q10432
  • 别名：
    ccq1; SPCC188.07; Coiled-coil quantitatively-enriched protein 1; Structural maintenance of chromosomes protein ccq1; SMC protein ccq1
  • 种属：
    Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
  • 基因功能参考文献：
    1. Together, these data provide a first glimpse into the architectural design of the Ccq1-Tpz1-Poz1 complex and reveals unique interactions that are important in maintaining the Schizosaccharomyces pombe telomere in a non-extendible state. PMID: 28807855
    2. Tpz1-Ccq1 interaction is required for Ccq1 Thr93 phosphorylation and telomerase recruitment. PMID: 25330395
    3. Tpz1 also participates in the activation of telomeres to the extendible state via its interaction with Ccq1 PMID: 24013504
    4. data suggest that Ccq1p and condensins Cut3p and Cut14p collaborate to mediate resolution of telomeres in mitosis and regulate intertelomeric clustering during interphase PMID: 20709788
    5. The loss of Ccq1 results in progressive telomere shortening and persistent ATR-dependent activation of Chk1 PMID: 19141478

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  • 亚细胞定位：
    Nucleus, nucleoplasm. Chromosome, telomere. Note=Associates with major heterochromatin, sub-telomeres, rDNA and the mat locus.
  • 数据库链接：

    KEGG: spo:SPCC188.07

    STRING: 4896.SPCC188.07.1

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