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  4. Recombinant Salmonella typhimurium Inositol phosphate phosphatase sopB (sopB), partial

Recombinant Salmonella typhimurium Inositol phosphate phosphatase sopB (sopB), partial

  • 中文名称：
    鼠伤寒沙门菌sopB重组蛋白
  • 货号：
    CSB-YP523230SXB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopB重组蛋白
  • 货号：
    CSB-EP523230SXB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopB重组蛋白
  • 货号：
    CSB-EP523230SXB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopB重组蛋白
  • 货号：
    CSB-BP523230SXB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopB重组蛋白
  • 货号：
    CSB-MP523230SXB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sopB
  • Uniprot No.：
    O30916
  • 别名：
    sopB; sigD; STM1091; Inositol phosphate phosphatase SopB; EC 3.1.3.-; Effector protein SopB
  • 种属：
    Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell.
  • 基因功能参考文献：
    1. These findings show that SopB suppresses host cell apoptosis by binding to TRAF6 and preventing mitochondrial reactive oxygen species generation. PMID: 27473656
    2. This work reveals the unique ability of bacterial effector protein SopB to utilize both its 4- and 5-phosphatase activities to regulate phosphoinositide dynamics to promote bacterial entry PMID: 26537021
    3. SopB secretion was also considerably impaired in the absence of dam. PMID: 24947562
    4. The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners PMID: 24075929
    5. Data found that SopB-dependent membrane translocation and phosphorylation of Akt are insensitive to the PI3K inhibitor wortmannin. PMID: 21779406
    6. Killing of Candida albicans filaments by Salmonella enterica serovar Typhimurium is mediated by sopB effectors, parts of a type III secretion system PMID: 21498643
    7. SopB may play a role in protecting mice from Salmonella colonization through activation of Akt2 PMID: 21555401
    8. SopB activity results in dissociation of a number of host-cell endocytic trafficking proteins from this compartment and inhibits Salmonella-containing vacuole-lysosome fusion. PMID: 20542249
    9. These data show that ubiquitination of SopB is not related to its intracellular stability but rather regulates its enzymatic activity at the plasma membrane and intracellular localization. PMID: 19614667
    10. essential for the establishment of Salmonella's intracellular replicative niche; responsible for maintaining high levels of phosphatidylinositol-three-phosphate in the membrane of the bacteria-containing vacuoles PMID: 15205533
    11. the N-terminal non-catalytic region exerts a specific effect on the actin cytoskeleton both in yeast and in human cell lines PMID: 16153243
    12. study demonstrates that SopB, SopE, SopE2 and SipA are the Salmonella pathogenicity island-1 secreted effectors responsible for disruption of tight junction structure and function PMID: 16869830
    13. Together, these results indicate that SPI-1 effector proteins SipA, SopA, SopB, SopD and SopE2 may participate in the late stages of Salmonella infection in mice. PMID: 17379731
    14. When expressed by microinjecting cDNA into epithelial cells forming confluent monolayers, wild-type SigD induced striking morphological and functional changes that were not mimicked by a phosphatase-deficient SigD mutant PMID: 17389247
    15. Study reports that the phosphoinositide phosphatase SopB, a Salmonella Typhimurium type III secreted effector protein, diversifies its function by localizing to different cellular compartments in a ubiquitin-dependent manner. PMID: 19379694
    16. S. Typhimurium stimulates intestinal inflammationby delivering through its type III secretion system the bacterial effector proteins SopE, SopE2, and SopB PMID: 19662166
    17. Prevents apoptosis in infected epithelial cells by activating the pro-survival kinase Akt. PMID: 15642738

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Phosphatase IpgD/SopB family
  • 数据库链接：

    KEGG: stm:STM1091

    STRING: 99287.STM1091

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