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  4. Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein ASH1 (ASH1), partial

Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein ASH1 (ASH1), partial

  • 中文名称：
    Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein ASH1(ASH1) ,partial
  • 货号：
    CSB-YP339430SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein ASH1(ASH1) ,partial
  • 货号：
    CSB-EP339430SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein ASH1(ASH1) ,partial
  • 货号：
    CSB-EP339430SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein ASH1(ASH1) ,partial
  • 货号：
    CSB-BP339430SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein ASH1(ASH1) ,partial
  • 货号：
    CSB-MP339430SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ASH1
  • Uniprot No.：
    P34233
  • 别名：
    ASH1; YKL185WTranscriptional regulatory protein ASH1; Daughter cells HO repressor protein
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. ASH1 is necessary to repress HO in daughter cells to block mating-type switching through its binding to HO promoter 5'-YTGAT-3' sites. Also involved in pseudohyphal growth.
  • 基因功能参考文献：
    1. Three X-ray structures of the ASH1-E3 localization element alone, in complex with its nuclear RBP She2p, and in the cytoplasmic synergistic ternary complex with She2p and She3p. PMID: 28092367
    2. ASH1 messenger ribonucleoprotein-core factors form stable complexes in absence of cargo RNA at physiological conditions. PMID: 25826656
    3. Recent advances have helped to draw an increasingly clear picture on the molecular mechanisms governing ASH1 mRNA localization from its co-transcriptional birth to its delivery at the site of destination PMID: 25482892
    4. ASH1 mRNA is transported to the bud tip by the class V myosin Myo4. PMID: 20457760
    5. We assessed ASH1 mRNA and Myo4p distribution more directly and found that their localization is impaired in cells expressing globular tail-lacking Myo4p. PMID: 20439999
    6. sequence-specific repressors, Ash1 is stably associated with Rpd3L PMID: 16314178
    7. the translation initiation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction PMID: 18413716
    8. Data show that ASH1 mRNA and She2 localize specifically to the nucleolus when their nuclear export is blocked. PMID: 18566598

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  • 亚细胞定位：
    Nucleus. Note=Preferentially accumulates in daughter cell nuclei at the end of anaphase.
  • 数据库链接：

    KEGG: sce:YKL185W

    STRING: 4932.YKL185W

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