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  4. Recombinant Saccharomyces cerevisiae Telomere elongation protein EST1 (EST1), partial

Recombinant Saccharomyces cerevisiae Telomere elongation protein EST1 (EST1), partial

  • 中文名称：
    酿酒酵母EST1重组蛋白
  • 货号：
    CSB-YP325486SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母EST1重组蛋白
  • 货号：
    CSB-EP325486SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母EST1重组蛋白
  • 货号：
    CSB-EP325486SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母EST1重组蛋白
  • 货号：
    CSB-BP325486SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母EST1重组蛋白
  • 货号：
    CSB-MP325486SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EST1
  • Uniprot No.：
    P17214
  • 别名：
    EST1; YLR233C; L8083.15Telomere elongation protein EST1; Ever shorter telomeres protein 1
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Directly involved in telomere replication. Associates with telomerase and during its interaction with CDC13, telomerase activity is promoted.
  • 基因功能参考文献：
    1. Recruitment of Est1 to telomeres via a Cdc13-Est1 fusion is sufficient to bypass the role of Ku in promoting telomere elongation. PMID: 24879463
    2. Autonomous localization of Est1p to the nucleus via the classical nuclear import pathway contributes to normal telomere length maintenance. PMID: 24906415
    3. Esl1 has no telomere-related functions, but contributes to the regulation of adaptive gene expression responses. PMID: 23893744
    4. It is possible that the intramolecular G-quadruplex promoting activity of Est1 is biologically relevant in telomere replication in vivo. PMID: 23376615
    5. There is a biochemical interaction between Est1 and the telomere binding protein Cdc13. Association of the Est1 protein with the telomerase catalytic core is not a regulatory event that contributes to telomere homeostasis. PMID: 23390975
    6. the telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro PMID: 21969561
    7. The tricotetrapeptide repeat of Est1 is required for Est2-mediated telomere length maintenance. PMID: 22011238
    8. These results demonstrate that one major functional role that Est1 brings to the telomerase complex is the capping or protection of telomeres. PMID: 21220516
    9. The authors show that the yeast telomerase subunit Est1p, known to be involved in telomerase recruitment to telomeres, can convert single-stranded telomeric G-rich DNA into a G-quadruplex structure in vitro in a Mg(2+)-dependent manner. PMID: 20098422
    10. telomerase assembly during G1 phase is regulated by Est1p stability, but assembly is insufficient to activate telomerase at telomeres PMID: 16862158
    11. dimerization of TLC1 is a functionally conserved feature of the RNA templates utilized by reverse transcriptases of both viral and cellular origins PMID: 17491007
    12. Maintenance of functional levels of Est2p late in the cell cycle requires that Est1p. PMID: 18949040

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  • 亚细胞定位：
    Nucleus. Chromosome, telomere.
  • 蛋白家族：
    EST1 family
  • 数据库链接：

    KEGG: sce:YLR233C

    STRING: 4932.YLR233C

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