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  4. Recombinant Saccharomyces cerevisiae Serine/threonine-protein kinase TOR2 (TOR2), partial

Recombinant Saccharomyces cerevisiae Serine/threonine-protein kinase TOR2 (TOR2), partial

  • 中文名称：
    酿酒酵母TOR2重组蛋白
  • 货号：
    CSB-YP330182SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母TOR2重组蛋白
  • 货号：
    CSB-EP330182SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母TOR2重组蛋白
  • 货号：
    CSB-EP330182SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母TOR2重组蛋白
  • 货号：
    CSB-BP330182SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母TOR2重组蛋白
  • 货号：
    CSB-MP330182SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TOR2
  • Uniprot No.：
    P32600
  • 别名：
    TOR2; DRR2; TSC14; YKL203C; Serine/threonine-protein kinase TOR2; EC 2.7.1.67; EC 2.7.11.1; Dominant rapamycin resistance protein 2; Phosphatidylinositol 4-kinase TOR2; PI4-kinase TOR2; PI4K TOR2; PtdIns-4-kinase TOR2; Target of rapamycin kinase 2; Temperature-sensitive CSG2 suppressor protein 14
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphatidylinositol 3-kinase homolog, component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4. In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6. Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase. TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway by activating the RHO1 guanine nucleotide exchange factor ROM2. TORC2 phosphorylates the AGC kinase YPK2, an upstream effector of the cell integrity pathway. TORC2 negatively regulates calcineurin-dependent stress signaling via phosphorylation of its effector SLM1-SLM2.
  • 基因功能参考文献：
    1. Data indicate that links between TOR complex 2 (TORC2)/kinase Ypk1 signaling and reactive oxygen species (ROS) as regulators of actin cytoskeleton. PMID: 25253719
    2. the function and physiological significance of Tor2. [Review] PMID: 24629393
    3. These results implicate TORC2-mediated actin filament regulation in the survival of low levels of DNA damage PMID: 24035500
    4. Far3-7-8-9-10-11 complex and PP2A (protein phosphatase 2A)-Rts1 antagonize TORC2 signaling by promoting dephosphorylation of TORC2 substrates. PMID: 22298706
    5. Direct Avo1-Ypk2 interaction is crucial for TORC2 signaling to the downstream Ypk2 pathway. PMID: 22207764
    6. TORC2 has been shown previously to negatively regulate calcineurin in part by phosphorylating two related proteins, Slm1 and Slm2, which associate with the PM via plextrin homology domains PMID: 22307609
    7. Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization PMID: 16055732
    8. TORC2 regulates ceramide biosynthesis in part by activating the AGC kinase Ypk2 and this step is antagonized by the Ca2+/calmodulin-dependent phosphatase calcineurin. PMID: 18249174
    9. Avo3p is a structural and signaling scaffold for TORC2. PMID: 18552287

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    PI3/PI4-kinase family
  • 数据库链接：

    KEGG: sce:YKL203C

    STRING: 4932.YKL203C

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