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  4. Recombinant Saccharomyces cerevisiae Proteasome activator BLM10 (BLM10), partial

Recombinant Saccharomyces cerevisiae Proteasome activator BLM10 (BLM10), partial

  • 中文名称：
    Recombinant Saccharomyces cerevisiae Proteasome activator BLM10(BLM10) ,partial
  • 货号：
    CSB-YP337453SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Proteasome activator BLM10(BLM10) ,partial
  • 货号：
    CSB-EP337453SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Proteasome activator BLM10(BLM10) ,partial
  • 货号：
    CSB-EP337453SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Proteasome activator BLM10(BLM10) ,partial
  • 货号：
    CSB-BP337453SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Proteasome activator BLM10(BLM10) ,partial
  • 货号：
    CSB-MP337453SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BLM10
  • Uniprot No.：
    P43583
  • 别名：
    BLM10; BLM3; YFL007W; YFL006WProteasome activator BLM10; Bleomycin resistance protein BLM10
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks.
  • 基因功能参考文献：
    1. data are consistent with a model in which Blm10 proteasome-mediated turnover of Dnm1 is required for the maintenance of mitochondrial function PMID: 24604417
    2. Blm10 represents the first proteolytic core particle-dedicated nuclear import receptor in yeast. PMID: 23982732
    3. Data propose that the cellular function of Blm10 is based on central core of the proteasome association and activation to promote the degradation of proteasome substrates. PMID: 22025621
    4. Blm10 functions in a proteasome-related process and it is required for the maintenance of mitochondrial function. PMID: 20227375
    5. Synthetic interactions between blm10Delta and other mutations that impair proteasome function show that Blm10 functions together with proteasomes in vivo PMID: 15778719
    6. Data show that Blm10 binds in a defined orientation to both ends of the 20 S particle and contacts all the proteasome alpha subunits. PMID: 16952374
    7. Blm10 and the 19 S activator with Pre4 have a partially redundant function in stabilizing nascent 20 S proteasomes and in promoting their activation PMID: 17911101
    8. Blm10 distinguishes between gate conformations and regulates the activation of core particles. PMID: 18927584

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    BLM10 family
  • 数据库链接：

    KEGG: sce:YFL007W

    STRING: 4932.YFL007W

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