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  4. Recombinant Saccharomyces cerevisiae Peroxiredoxin TSA1 (TSA1)

Recombinant Saccharomyces cerevisiae Peroxiredoxin TSA1 (TSA1)

  • 中文名称：
    酿酒酵母TSA1重组蛋白
  • 货号：
    CSB-YP335979SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母TSA1重组蛋白
  • 货号：
    CSB-EP335979SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母TSA1重组蛋白
  • 货号：
    CSB-EP335979SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母TSA1重组蛋白
  • 货号：
    CSB-BP335979SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母TSA1重组蛋白
  • 货号：
    CSB-MP335979SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TSA1
  • Uniprot No.：
    P34760
  • 别名：
    TSA1; TPX1; TSA; ZRG14; YML028W; Peroxiredoxin TSA1; Prx; EC 1.11.1.15; Cytoplasmic thiol peroxidase 1; cTPx 1; Protector protein; PRP; Thiol-specific antioxidant protein 1; Thioredoxin peroxidase type Ia; TPx type Ia; Thioredoxin-dependent peroxide reductase
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-196
  • 氨基酸序列
    VAQVQKQAP TFKKTAVVDG VFDEVSLDKY KGKYVVLAFI PLAFTFVCPT EIIAFSEAAK KFEEQGAQVL FASTDSEYSL LAWTNIPRKE GGLGPINIPL LADTNHSLSR DYGVLIEEEG VALRGLFIID PKGVIRHITI NDLPVGRNVD EALRLVEAFQ WTDKNGTVLP CNWTPGAATI KPTVEDSKEY FEAANK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Protects the cell against the oxidative stress caused by nascent-protein misfolding and aggregation. Relays hydrogen peroxide as a signal to the transcription factor YAP1 by inducing the formation of intramolecular disulfide bonds in YAP1, which causes its nuclear accumulation and activation. Can act alternatively as peroxidase and molecular chaperone. Oxidative stress and heat shock exposure cause a reversible shift of the protein structure from low MW species to high MW complexes, triggering a peroxidase-to-chaperone functional switch. The chaperone function of the protein enhances resistance to heat shock.
  • 基因功能参考文献：
    1. The critical molecular event allowing the Tsa1 to chaperone switch is the enzyme assembly into high molecular weight structures brought about by enzyme hyperoxidation and sulfinylation. PMID: 26335398
    2. Tsa1 localises to the sites of protein aggregation and protects against protein-aggregate-induced oxidative stress. PMID: 24424024
    3. It appears to control the cellular reactive oxygen species. PMID: 24418709
    4. Tsa1, the major peroxiredoxin, is required for telomere length maintenance. PMID: 23590194
    5. Glu50 and Arg146 are important for the Tsa1-Trx interaction. These results may impact the comprehension of downstream events of signaling pathways that are triggered by the oxidation of critical Cys residues, such as Trx PMID: 22985967
    6. Tsa1 is required to ensure yeast longevity and that caloric restriction extends yeast life span, in part, by counteracting age-induced hyperoxidation of this peroxiredoxin PMID: 21884982
    7. TSA1-B7 encodes for a novel dominant form of peroxiredoxin, and establishes a new connection between oxidative stress and aging PMID: 20729566
    8. An elevation in intracellular dNTP production was observed in tsa1 mutants. PMID: 19851444
    9. Tsa1 normally functions to chaperone misassembled ribosomal proteins, preventing the toxicity that arises from their aggregation PMID: 16251355
    10. Results suggest that cytosolic thioredoxin peroxidase I is specifically important in the protection of yeast with mitochondrial dysfunction due to its functional versatility as an antioxidant, chaperone and modulator of gene expression. PMID: 16441666
    11. Implications for the role of peroxiredoxins in stress and growth control. PMID: 18271751
    12. Expression of either Tsa1 or PrxI prevented Bax-induced cell death. These data indicate that PrxI is an orthologue of Tsa1. PrxI and Tsa1 seem to act on the same substrates in vivo and share similar mechanisms of function. PMID: 18281480
    13. hyperoxidized Prx, Tsa1p-SO(3)H, with enhanced molecular chaperone activity and suggest that Tsa1p-SO(3)H is a marker of cumulative oxidative stress in cells PMID: 18725414
    14. Tsa1 can interact with Yap1 via disulfide linkages and induce the formation of intramolecular disulfide bonds in Yap1 in ybp1-1 cells. PMID: 19106090
    15. Tsa1 acts to protect S. cerevisiae cells against toxic levels of DNA damage. PMID: 19543365

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peroxiredoxin family, AhpC/Prx1 subfamily
  • 数据库链接：

    KEGG: sce:YML028W

    STRING: 4932.YML028W

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