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  4. Recombinant Saccharomyces cerevisiae Nuclear polyadenylated RNA-binding protein NAB2 (NAB2), partial

Recombinant Saccharomyces cerevisiae Nuclear polyadenylated RNA-binding protein NAB2 (NAB2), partial

  • 中文名称：
    酿酒酵母NAB2重组蛋白
  • 货号：
    CSB-YP330173SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母NAB2重组蛋白
  • 货号：
    CSB-EP330173SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母NAB2重组蛋白
  • 货号：
    CSB-EP330173SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母NAB2重组蛋白
  • 货号：
    CSB-BP330173SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母NAB2重组蛋白
  • 货号：
    CSB-MP330173SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NAB2
  • Uniprot No.：
    P32505
  • 别名：
    NAB2; YGL122C; Nuclear polyadenylated RNA-binding protein NAB2
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This essential protein binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions.
  • 基因功能参考文献：
    1. Binding A11G RNA induces dimerization of Zn fingers 5-7 mediated by the novel spatial arrangement of the fingers promoting each RNA chain binding two protein chains. The dimerization of Nab2 induced by RNA binding provides a basis for understanding its function in both poly(A) tail length regulation and in the compaction of mature transcripts to facilitate nuclear export. PMID: 28180315
    2. Studies provide evidence Nab2 is important for efficient RNAPIII transcription initiation in addition to its known functions in gene expression, i.e., poly(A) tail length control, mRNP biogenesis, and nuclear mRNA export. PMID: 27049816
    3. Nab2p uses its last two CCCH domains and its RGG-box to form a Nab2p/poly(A) complex of unusual topology that defines and controls mRNA poly(A) tail length by preventing 3'-end accessibility to the poly(A) polymerase PMID: 18304944
    4. absence of Nab2p results in robust nuclear mRNA decay by the ribonucleolytic RNA exosome. PMID: 26119729
    5. Nab2 increases TFIIIB binding to the promoter, thereby stimulating RNAPIII transcription. PMID: 26220998
    6. Nab2p tandem zinc finger TZF34 exhibits a distinctive two-fold symmetry of the zinc centers with mutual recognition of histidine ligands. PMID: 23994011
    7. A seven-residue segment of the PY-NLS of Nab2 is observed to bind Kapbeta2 in an extended conformation and occupies the same PY-NLS binding site observed in other Kapbeta2.PY-NLS structures. PMID: 23535894
    8. the solution structure of Nab2 ZnF5-7 and their interaction with polyadenosine-RNA PMID: 22560733
    9. nuclear mRNP surveillance step involves targeting of Rrp6p by Nab2p-bound pA-tailed RNPs and that pre-mRNA abundance is regulated at this level PMID: 22683267
    10. Nab2 function is a central player in the general and coordinated control of gene expression from transcription to translation. PMID: 21680710
    11. Nab2 binding to RNA is critical for proper control of poly(A) tail length. PMID: 20554526
    12. data show that Nab2 is preferentially associated with THO/TREX complex members and with many if not all poly(A)+ mRNAs; this supports a model in which Nab2 is involved in general mRNP assembly and export PMID: 19840948
    13. N-terminal Nab2 domain is distinct from its RNA binding domains suggesting Nab2 could bind Gfd1 and RNA simultaneously PMID: 15208322
    14. these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins PMID: 17630287
    15. NAB2 functions together with PUB1 to modulate mRNA stability and strengthen a model where nuclear events are coupled to the control of mRNA turnover in cytoplasm. PMID: 17636033
    16. The N-terminal domain of Nab2 (residues 1-97) mediates interactions with both the C-terminal globular domain of the nuclear pore-associated protein, myosin-like protein 1 (Mlp1), and the mRNA export factor, Gfd1. PMID: 18190927
    17. Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export PMID: 18682389

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NAB2 family
  • 数据库链接：

    KEGG: sce:YGL122C

    STRING: 4932.YGL122C

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