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  4. Recombinant Saccharomyces cerevisiae Iron-regulated transcriptional activator AFT1 (AFT1), partial

Recombinant Saccharomyces cerevisiae Iron-regulated transcriptional activator AFT1 (AFT1), partial

  • 中文名称：
    Recombinant Saccharomyces cerevisiae Iron-regulated transcriptional activator AFT1(AFT1) ,partial
  • 货号：
    CSB-YP324340SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Iron-regulated transcriptional activator AFT1(AFT1) ,partial
  • 货号：
    CSB-EP324340SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Iron-regulated transcriptional activator AFT1(AFT1) ,partial
  • 货号：
    CSB-EP324340SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Iron-regulated transcriptional activator AFT1(AFT1) ,partial
  • 货号：
    CSB-BP324340SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Saccharomyces cerevisiae Iron-regulated transcriptional activator AFT1(AFT1) ,partial
  • 货号：
    CSB-MP324340SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    AFT1
  • Uniprot No.：
    P22149
  • 别名：
    AFT1; RCS1; YGL071WIron-regulated transcriptional activator AFT1; Activator of iron transcription protein 1
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable transcription factor that activates the genes for FRE1, FRE2 and FET3 in response to iron deprivation. Also required for the expression of LSO1. Iron could interact directly with AFT1 and inhibits its activity.
  • 基因功能参考文献：
    1. Taken together, these results suggest that the protein-protein interaction between Sit1 and Aft1 is an important factor in the ferrioxamine B uptake activity of Sit1. PMID: 26323600
    2. Aft1p dissociates from its target promoters under iron-replete conditions due to an interaction between Aft1p and the monothiol glutaredoxin Grx3p or Grx4p (Grx3/4p). PMID: 23045394
    3. These data suggest that Aft1p and Mac1p might corporately regulate transcription of CTR2. PMID: 22683637
    4. investigation of role of Aft-1 (and YAH1) in regulation of iron metabolism under various growth conditions (e.g., low iron in media) PMID: 21361388
    5. Aft1/Aft2 activation of the iron regulon depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis PMID: 15649888
    6. different cis-regulatory elements are found for Aft1 and Aft2, and transcription analysis indicates that Aft1 is more specific for the canonical iron-responsive element TGCACCC than is Aft2. PMID: 16024809
    7. These findings suggest that cisplatin activates Aft1 through the inhibition of iron uptake into the cells, after which the expression of Aft1 target genes involved in iron uptake might be induced. PMID: 17096368
    8. These results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner. PMID: 17538022
    9. These results suggest that Aft1 interacts with Arn3 and may regulate the ubiquitination of Arn3 in the cytosolic compartment. PMID: 19469713

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: sce:YGL071W

    STRING: 4932.YGL071W

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