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  4. Recombinant Saccharomyces cerevisiae ATP-dependent DNA helicase II subunit 1 (YKU70), partial

Recombinant Saccharomyces cerevisiae ATP-dependent DNA helicase II subunit 1 (YKU70), partial

  • 中文名称：
    酿酒酵母YKU70重组蛋白
  • 货号：
    CSB-YP339296SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母YKU70重组蛋白
  • 货号：
    CSB-EP339296SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母YKU70重组蛋白
  • 货号：
    CSB-EP339296SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母YKU70重组蛋白
  • 货号：
    CSB-BP339296SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母YKU70重组蛋白
  • 货号：
    CSB-MP339296SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    YKU70
  • Uniprot No.：
    P32807
  • 别名：
    YKU70; HDF1; NES24; YMR284W; YM8021.10ATP-dependent DNA helicase II subunit 1; EC 3.6.4.12; ATP-dependent DNA helicase II subunit Ku70; High affinity DNA-binding factor subunit 1
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
  • 基因功能参考文献：
    1. We found that the yku70-R456E mutant strain, which has markedly reduced association of Ku at telomeres, maintained WT levels of TLC1 nuclear localization. PMID: 24879463
    2. Yku70 sumoylation upon DNA association strengthens Ku-DNA interaction to promote multiple functions of Ku PMID: 24567323
    3. The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation. [YKU70] PMID: 21441303
    4. Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. PMID: 20729809
    5. Ku inhibits Exo1-dependent double-strand break end resection in the absence of the MRX complex in vitro. PMID: 20834227

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  • 亚细胞定位：
    Nucleus. Chromosome, telomere.
  • 蛋白家族：
    Ku70 family
  • 数据库链接：

    KEGG: sce:YMR284W

    STRING: 4932.YMR284W

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