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  4. Recombinant Rat Unconventional myosin-Va (Myo5a), partial

Recombinant Rat Unconventional myosin-Va (Myo5a), partial

  • 中文名称：
    大鼠Myo5a重组蛋白
  • 货号：
    CSB-YP889886RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Myo5a重组蛋白
  • 货号：
    CSB-EP889886RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Myo5a重组蛋白
  • 货号：
    CSB-EP889886RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Myo5a重组蛋白
  • 货号：
    CSB-BP889886RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Myo5a重组蛋白
  • 货号：
    CSB-MP889886RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Myo5a
  • Uniprot No.：
    Q9QYF3
  • 别名：
    Myo5a; Unconventional myosin-Va; Dilute myosin heavy chain; non-muscle
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.
  • 基因功能参考文献：
    1. This study identified in vivo neuropathological and biochemical alterative changes involved in the pathogenesis of a spontaneous autosomal recessive movement disorder in a mutant Myo5a juvenile rat model. PMID: 29217155
    2. Insulin signaling to the molecular switch Rab8A connects with the motor protein MyoVa to mobilize GLUT4 vesicles toward the muscle cell plasma membrane. PMID: 24478457
    3. targeting of mRNAs to the dendrites is mediated by a mechanism that is dependent on actin and Myosin Va. PMID: 24637809
    4. Data demonstrate that myosin-Va is a component of a heterogeneous population of ribonucleoprotein particles of different sizes and composition, both in brain and peripheral nervous system PMID: 24272908
    5. Myosin-Va mediates cell-to-cell transfer of RNA from Schwann cells to axons. PMID: 23626749
    6. Multiple binding partners of BR-MyoVa regulate SG transport, and this molecular mechanism is universally used by neuronal, endocrine and neuroendocrine cells. PMID: 21985333
    7. Myosin-Va presented significantly lower levels of both mRNA and protein in diabetic than those observed in non-diabetic animals. PMID: 21842169
    8. Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
    9. These data suggest an implication of myosin Va and Rab3D in the maturation of SGs where they participate in overlapping but not identical tasks. PMID: 21080055
    10. We suggest a model where myosin Va acts as an actin-dependent vesicle motor that facilitates retrograde axonal transport. PMID: 19787448
    11. possible involvement of M-Va in nerve regeneration processes PMID: 11977091
    12. Expression of a dominant-negative tail domain of myosin Va caused clustering of secretory granules close to the cell periphery, a loss of their cortical restriction and a reduction in their motility in the actin cortex. PMID: 12615975
    13. interaction between myosin-Va and syntaxin-1A is involved in exocytosis. Myosin-Va neck contributes to the large step size and also to the regulation of exocytosis by Ca2+. PMID: 16030255
    14. insulin granules are transported through the actin network via both myosin 5a-mediated transport and via passive diffusion PMID: 16190983
    15. Myosin Va was identified as the specific motor protein that catalyzes the directional transport of AMPA receptors into spines during activity-dependent synaptic plasticity. PMID: 18311135
    16. These data provide the first systematic description of myosin-Va localization in the major endocrine organs of rat. PMID: 18568366
    17. Results suggest that myosinVa-tail causes the liberation of large dense core vesicles from the actin cytoskeleton, leading to an increase in exocytosis in the cultured hippocampal neurons. PMID: 19214741

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  • 相关疾病：
    Defects in Myo5a are a cause of Dilute-opisthotonus (dop). Dop rats have diluted coat color and are occasionally associated with severe neurological disorders.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 数据库链接：

    KEGG: rno:25017

    UniGene: Rn.44865

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