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  4. Recombinant Rat Tyrosine-protein kinase JAK2 (Jak2), partial

Recombinant Rat Tyrosine-protein kinase JAK2 (Jak2), partial

  • 中文名称：
    大鼠Jak2重组蛋白
  • 货号：
    CSB-YP717274RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Jak2重组蛋白
  • 货号：
    CSB-EP717274RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Jak2重组蛋白
  • 货号：
    CSB-EP717274RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Jak2重组蛋白
  • 货号：
    CSB-BP717274RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Jak2重组蛋白
  • 货号：
    CSB-MP717274RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Jak2
  • Uniprot No.：
    Q62689
  • 别名：
    Jak2; Tyrosine-protein kinase JAK2; EC 2.7.10.2; Janus kinase 2; JAK-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
  • 基因功能参考文献：
    1. The investigation demonstrated that the serum levels of FGF23 and the phosphorylation levels of JAK2, STAT1, and STAT3 were up-regulated in the ovariectomy (OVX) + NVP-BGJ398 group while were down-regulated in the OVX + Anti-FGF23 group than that in the OVX group. PMID: 28782829
    2. DUSP19 up-regulation inhibited IL-1beta-induced chondrocytes apoptosis and MMPs expression through inactivating JAK2/STAT3 pathway. PMID: 29174854
    3. The studies findings implicate that JAK2/STAT3 pathway plays the vital role in cerebral ischemia/reperfusion injury protection from activating epidermal growth factor receptor. PMID: 29061394
    4. PPARgamma agonist ROZ alleviated steatosis through reducing SOCS3 expression by inhibiting JAK2/STAT3 in hepatocytes. PMID: 29550470
    5. The age-related modifications in the JAK/STAT/SOCS signaling as well as the age-associated pathological changes in myocardial structure are of particular interest as they provide further insight in age-associated heart pathologies and represent potential targets for cardioprotective and therapeutic approaches. PMID: 28782583
    6. JAK2 and STAT3 proteins in pancreatic exocrine cells were activated by high-dose linoleic acid via phosphorylation and nuclear localization of phosphorylated STAT3. PMID: 27450794
    7. The JAK2-STAT3 pathway, a survival signaling pathway, is linked to apoptosis. PMID: 27337676
    8. Catalpol affects neuroprotection and angiogenesis via the JAK2/STAT3 signaling pathway, up-regulating VEGF expression. PMID: 27301615
    9. Hepatocyte growth factor prevents XO activation following hypoxia/reoxygenation primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Calcium. PMID: 27573711
    10. JAK2 expressed in the dorsal root ganglion plays a role in the sensitization of nociceptors in the peripheral tissue. Janus kinase 2 activation participates in prostaglandin E2-induced hyperalgesia. PMID: 27717845
    11. These results demonstrate that Notch signaling protects against burn-induced myocardial injury through JAK2/STAT3 signaling, which activates the expression of MnSOD and leads to decreased reactive oxygen species levels. PMID: 27057278
    12. Spermine suppresses ROS accumulation to decrease cardiomyocytes apoptosis in high glucose condition, which may be attributed to the inhibition of p38/JNK and JAK2 activation and its natural antioxidative property. PMID: 26884823
    13. results suggest that a subpopulation of TLR4-activated microglia may survive by producing GM-CSF and up-regulating GM-CSFR. This autocrine GM-CSF pathway may activate the JAK2/STAT5 signaling pathway PMID: 26802935
    14. Suggest that AG490 may prevent the occurrence of heatstroke via inhibiting the JAK2/STAT3 pathway and the systemic inflammatory responses. PMID: 26261556
    15. During early reperfusion the Reactive Oxygen Species/JAK2/STAT3 pathways play a crucial role in the intermittent hypobaric hypoxia preconditioning-maintained intracellular Ca2+ homeostasis via the improvement of postischemic SERCA2 activity. PMID: 25731682
    16. findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements PMID: 25986861
    17. We propose a hypothesis accounting for memory impairment related to MHE: DA-dependent inactivation of the JAK2/STAT3 axis causes memory loss through cholinergic dysfunction PMID: 25500624
    18. HDAC2 might be a downstream effector of Jak2 to mediate cardiac hypertrophic response by pressure overload or Ang-II. PMID: 25380525
    19. CX3CL1 activates Jak2-Stat5alpha-ERK1/2 signaling through CX3CR1, thereby triggering integrin-dependent machinery reorganization to allow chemotactic migration of bone marrow-derived mesenchymal stem cells towards an ischemic cerebral lesion. PMID: 25559502
    20. Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak2 and Stat3 pathway PMID: 25537973
    21. These data demonstrate for the first time that KRV-induced islet destruction is associated with beta cell infection and intra-islet innate immune upregulation early in the disease process. PMID: 25129435
    22. Intrauterine growth restriction alters specific targets in the JAK/STAT signalling pathway, with altered JAK2 and STAT3 potentially contributing to the increased risk of cardiovascular disease. PMID: 24965138
    23. Brain astrocyte migration depends on MMP-9 induction which requires the Jak2 pathway. PMID: 24018979
    24. Basal renal IL6 mRNA and phosphorylation of its downstream signaling molecule STAT3 were increased as was the product of its action, the suppressor of cytokine signaling 3 (SOCS3) mRNA. PMID: 24463190
    25. Our study substantiates the important cell-intrinsic role of JAK2 in hepatic stellate cells for development of liver fibrosis. PMID: 24619965
    26. The results indicate that OMT exhibits substantial therapeutic potential for the treatment of septic shockinduced myocardial injury through inhibition of the JAK2/STAT3 signaling pathway. PMID: 23404057
    27. H2S postconditioning effectively protects isolated Ischemia/Reperfusion rat hearts via activation of the JAK2/STAT3 signaling pathway. PMID: 22948409
    28. melatonin pretreatment can attenuate IRI by reducing IR-induced mitochondrial oxidative damage via the activation of the JAK2/STAT3 signaling pathway. PMID: 23796350
    29. the genistein-mediated AMPK phosphorylation occurred via JAK2, which was possibly activated through a mechanism that involved cAMP. Additionally, the genistein-mediated induction of fatty acid oxidation genes involved PGC1alpha and PPARdelta. PMID: 24013029
    30. Inhibitors of JAK2 (AG 490) and STAT3 (STAT3 peptide) blocked the increase in BrdUrd(+) cell numbers. PMID: 23869758
    31. Ccdc80 preferentially binds activated, tyrosyl-phosphorylated JAK2 but not kinase-inactive JAK2. PMID: 23449887
    32. Tumor necrosis factor (TNF)alpha may regulate interleukin (IL)-6 production through its activation/interaction of janus kinase (JAK2)/STAT signaling. PMID: 22697788
    33. Data show that S100A4 is predominantly expressed in hypoxic rhomboid smooth muscle cells, and regulated by the activation of JAK2-STAT3 signal pathway, which is dependent on hypoxia-induced HIF-1alpha expression. PMID: 22561747
    34. Curcumin attenuates myocardial ischemia reperfusion injury through the activation of the JAK2/STAT3 signaling pathway, which transmits a survival signal to the myocardium. PMID: 22466958
    35. Findings define a molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling. PMID: 22125600
    36. PDGF-beta receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition. PMID: 21929289
    37. VEGF expression is attenuated by glucose in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling PMID: 18798867
    38. A novel link between PKA and JAK2 by which nuclear JAK2 signaling controls adrenal steroidogenesis by increasing the stability of CREB, is described. PMID: 21808064
    39. Data suggest that inhibition of NADPH oxidase may be beneficial for prevention and treatment of pancreatitis by suppressing Jak2/Stat3 and MAPKs and expression of TGF-beta1 in pancreatic acinar cells. PMID: 21509626
    40. Expression of JAK2 increased immediately, peaked at 3h after traumatic parietal contusion and decreased thereafter. The JAK2/STAT pathway may be involved in the neurological function recovery after TBI. PMID: 21596098
    41. Rosuvastatin treatment improves the efficacy of mesenchymal stem cell transplantation in infarcted hearts by activation of the JAK2-STAT3 signaling pathway. PMID: 21502705
    42. Inhibition of JAK2 could have a role in apoptosis induced by neurotoxin-induced m methyl-4-phenylpyridinium (by inhibiting p-STAT1 and increasing p-STAT3). PMID: 20817061
    43. marked JAK-2 expression is shown in the rAIA in mixed inflammatory cells (macrophages and neutrophils), mast cells, and bone marrow elements PMID: 20724918
    44. The local renin-angiotensin system may play a role in the transdifferentiation of renal tubular cells through the AT2 receptor and its JAK2 signal pathway. PMID: 19781194
    45. JAK2/STAT3 signaling may be critical in the early stages of hepatic stellate cells transdifferentiation. PMID: 20976841
    46. Expression of JAK2 and PTP-1B is elevated in in adipose tissue of obese rats induced by high-fat diet. Candesartan treatment can reduce expression. PMID: 20979831
    47. Phosphorylation of JAK2 and STAT3 in cortical neurons is enhanced by hypoxic preconditioning, which alleviates the neuronal damage caused by subsequent secreted phospholipase III treatment. PMID: 20492356
    48. Puerarin can effectively attenuate liver lipid disorder and inflammation by improving the leptin resistance and enhancing the expressions of leptin receptor mRNA and P-JAK2/P-STAT3 proteins. PMID: 18782535
    49. in the thymus, Fyn acts as a tyrosine kinase that transduces the leptin signal independently of JAK2 activation, and mediates some of the immunomodulatory effects of leptin in this tissue PMID: 19888448
    50. Compared with low glucose control group, the expression of JAK2 was significantly up-regulated in lomerular mesangial cells under high concentration of glucose. PMID: 18611343

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  • 亚细胞定位：
    Endomembrane system; Peripheral membrane protein. Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
  • 组织特异性：
    Ubiquitously expressed throughout most tissues.
  • 数据库链接：

    KEGG: rno:24514

    STRING: 10116.ENSRNOP00000021218

    UniGene: Rn.18909

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