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  4. Recombinant Rat Tuberin (Tsc2), partial

Recombinant Rat Tuberin (Tsc2), partial

  • 中文名称：
    大鼠Tsc2重组蛋白
  • 货号：
    CSB-YP342640RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Tsc2重组蛋白
  • 货号：
    CSB-EP342640RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Tsc2重组蛋白
  • 货号：
    CSB-EP342640RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Tsc2重组蛋白
  • 货号：
    CSB-BP342640RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Tsc2重组蛋白
  • 货号：
    CSB-MP342640RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tsc2
  • Uniprot No.：
    P49816
  • 别名：
    Tsc2; Tuberin; Tuberous sclerosis 2 protein homolog
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
  • 基因功能参考文献：
    1. TFE3 activation by mTORC1 signaling is involved in the development of abnormal ductal structures in Tsc2 knockout teratomas. PMID: 26352760
    2. Formation of ROS and activity of NADPH oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells. PMID: 27278252
    3. Heterozygous TSC2 mutation not only affects the liver metabolism, but also skeletal muscle metabolism, via mitochondrial dysfunction. PMID: 27031579
    4. Therefore, we conclude that glycolysis is restrained in the livers of TSC2 heterozygous mutant rats, and these defects lead to abnormal production of acetoacetate. PMID: 26550928
    5. In vitro differentiation experiments using these ESCs combined with in vivo experiments may reveal the mechanism of the tissuespecific pathogenesis caused by the Tsc2 mutation and identify specific new therapeutic targets. PMID: 25738543
    6. The N525S Tsc2 variant causes dominant embryonic lethality in Eker rats. PMID: 25088526
    7. In conclusion, dendritic spine abnormalities in TSC neurons may be caused through activation of Rheb, but not through of mTORC1. PMID: 24889507
    8. these results demonstrate that TSC2-deficient cells have enhanced choline phospholipid metabolism and reveal a novel function of the TSC proteins in choline lysoglycerophospholipid metabolism PMID: 25780943
    9. oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2 PMID: 24444419
    10. Kidney mass was significantly greater in partially tuberin-deficient (TSC2(+/-) ) diabetic rats than wild-type diabetic rats. TSC2(+/-) rats exhibited significant increases in the levels of phospho-tuberin and fibronectin expression in the kidney cortex. PMID: 22904348
    11. Our study shows that Tsc2 haploinsufficiency and developmental status epilepticus in wild-type and Tsc2 (+/-) rats independently lead to autistic-like social deficit behaviors. PMID: 20927644
    12. Data demonstrate that mTORC2-dependent activation of RhoA is required for TSC2-null cell growth and survival. PMID: 21482669
    13. the tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes, mediated in part by cleavage of PARP by YY1. PMID: 21289215
    14. Results describe the expression of Nth1 and Tsc2 genes during disease progression in hepatitis/liver tumorigenesis the Long-Evans Cinnamon rat. PMID: 20033472
    15. TSC2 has a role in controlling cell polarity and migration by regulating CDC42 and RAC1 activation PMID: 20530489
    16. Aberrant expression of HMGA2 in uterine leiomyoma is associated with loss of TSC2 tumor suppressor gene function. PMID: 12097287
    17. Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity. PMID: 12110509
    18. The complex of this protein with hamartin negatively regulates beta-catenin signaling activity. PMID: 12511557
    19. Polycystic kidney results from a loss of the tuberous sclerosis 2 tumor suppressor gene during development. PMID: 12547704
    20. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma is associated with loss of Tsc-2 tumor suppressor gene. PMID: 12750296
    21. the TSC1.TSC2 complex is regulated by pam and its ortholog highwire PMID: 14559897
    22. In Eker rats, many if not all cytomegalic neurons of a cortical tuber occur in the absence of allelic loss. PMID: 14566415
    23. restoration of tuberin expression in QT-RRE cells by transient transfection with Tsc-2 cDNA substantially decreased both ERK and B-Raf activity, with only modest changes in Raf-1 activity PMID: 14612383
    24. Tsc2 is a component of membrane microdomains and mediates caveolin-1 localization in post-Golgi transport. PMID: 15093748
    25. Mutant rats are models for hereditary renal caricnoma (review) PMID: 15579027
    26. The TSC2 modulates actin dynamics and cell adhesion and the TSC1-binding domain (TSC2-HBD) is essential for this function of TSC2. PMID: 15611338
    27. TSC2+/- rats, which are virtually free of cerebral hamartomas, exhibit enhanced episodic-like memory and enhanced responses to chemically-induced kindling. PMID: 16300636
    28. Increased lymphangioleiomyomatosis (LAM) cell growth is associated with constitutive S6K1 activation, which is extinguishable by TSC2 expression. PMID: 16424383
    29. REDD1 functions upstream of Tuberin and Rheb to down-regulate mTOR signaling in response to dexamethasone PMID: 17074751
    30. study presents the cytoplasmic/nuclear distribution of tuberin in cell lines PMID: 17458623
    31. in granulosa cells, FSH uses a protein kinase A-/ERK-dependent pathway to stimulate TSC2 phosphorylation and mTOR signaling PMID: 17510244
    32. IFNbeta augments TSC2-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. PMID: 18094073
    33. These results demonstrate that OGG1 localizes with tuberin preferentially in kidney cortex. Loss of tuberin is accompanied by the loss of OGG1 contributing to tumorigenesis. PMID: 18218111
    34. there is a dissociation of TSC2 and mTOR phosphorylation in vivo. PMID: 18670866
    35. G1556S-type mutation-transgenic (GSM-Tg) rats exhibited suppression of macroscopic renal tumors following N-ethyl-N-nitrosourea treatment PMID: 18695678
    36. findings show that endoplasmic reticulum (ER) stress regulates TSC1/TSC2 complex to limit mTOR activity PMID: 19420259

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  • 相关疾病：
    A germline insertion in Tsc2 is the cause of the Eker rat model of inherited cancer susceptibility. Gives rise to a spectrum of epithelial and nonepithelial neoplasms.
  • 组织特异性：
    CNS, uterus, heart, skeletal muscle, kidney and spleen.
  • 数据库链接：

    KEGG: rno:24855

    STRING: 10116.ENSRNOP00000016221

    UniGene: Rn.5875

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