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  4. Recombinant Rat Transient receptor potential cation channel subfamily V member 4 (Trpv4), partial

Recombinant Rat Transient receptor potential cation channel subfamily V member 4 (Trpv4), partial

  • 中文名称：
    大鼠Trpv4重组蛋白
  • 货号：
    CSB-YP863666RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Trpv4重组蛋白
  • 货号：
    CSB-EP863666RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Trpv4重组蛋白
  • 货号：
    CSB-EP863666RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Trpv4重组蛋白
  • 货号：
    CSB-BP863666RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Trpv4重组蛋白
  • 货号：
    CSB-MP863666RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trpv4
  • Uniprot No.：
    Q9ERZ8
  • 别名：
    Trpv4; Vroac; Transient receptor potential cation channel subfamily V member 4; TrpV4; Osm-9-like TRP channel 4; OTRPC4; Vanilloid receptor-related osmotically-activated channel; VR-OAC
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Together with PKD2, forms mechano- and thermosensitive channels in cilium. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes. Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes. Together with AQP5, controls regulatory volume decrease in salivary epithelial cells. Required for normal development and maintenance of bone and cartilage. In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus.
  • 基因功能参考文献：
    1. HO-2 and TRPV4 were also confirmed to form a complex in SFO neurons. PMID: 27436489
    2. TRPV4 channels play an important role in the regulation of the adrenergic vascular tone of pulmonary artery smooth muscle cells, but TRPV4 activation mechanism(s) and signaling pathways remain unclear. PMID: 29537229
    3. This study was undertaken to investigate the mechanism underlying TRPV4-mediated myocardial ischemia/reperfusion injury. PMID: 28542130
    4. In conclusion, TRPV4 differently regulates insulin mRNA expression in INS-1E cells via ERK1/2 and NO-dependent mechanisms. PMID: 28359774
    5. These data indicate that TRPV4 is functionally expressed in vestibular ganglion (VG) neurons as an ion channel and that TRPV4 likely participates in VG neurons for vestibular neurotransmission as an osmoreceptor and/or mechanoreceptor. PMID: 27705979
    6. irisin may induce endothelium-dependent vasodilation by activating Ca(2+) influx into endothelial cells via TRPV4 channels PMID: 29097199
    7. findings demonstrate that FHH rat cerebral arterial myocytes express mRNA transcript and translated protein for TRPV4 channel and display TRPV4-like single-channel cationic current activity that was stretch-sensitive and activation of which increased the open state probability of KCa single-channel current in these arterial myocytes PMID: 28472069
    8. Results indicate that osmosensitive transient receptor potential channel 4 protein (TRPV4) controls hypotonic-induced responses in synoviocytes. PMID: 28274876
    9. TRPV4 is expressed in mouse and rat gastric epithelium and contributes to ATP release and gastric emptying. PMID: 27350729
    10. these results support the link between TRPV4 and p38 and their intermediary role for neuropathic pain in rats with chronic compression of the dorsal root ganglion. PMID: 27366753
    11. Data suggested that the impairment of TRPV4-mediated Ca2+ signaling in epithelial cells contributed to the age-related decrease of flow-induced vessel dilation in mesenteric arteries. PMID: 26947561
    12. TRPV4 channel activity modulates uterine contractility and might represent a therapeutic target to address preterm labor. PMID: 26702092
    13. Overexpression and altered cellular distribution of TRPV4 observed in focal cortical dysplasia suggest that TRPV4 may potentially contribute to the epileptogenesis of focal cortical dysplasia PMID: 26842013
    14. Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol PMID: 26294342
    15. Aquaporin-mediated fast swelling kinetics play a key role in cell volume regulation (together with TRPV4) and calcium signaling in astrocytes PMID: 26413835
    16. hyperglycaemia and diabetes reduce the molecular and functional expression of TRPV4 channels in retinal microvascular endothelial cells. PMID: 26047504
    17. We conclude that flow-induced increases in Cai are mediated primarily by TRPV4 in the rat mTAL. PMID: 25980432
    18. TRPV4 and calcium-activated potassium channels functionally couple as osmosensors in the paraventricular nucleus PMID: 25421636
    19. TRPV4 could inhibit hepatic stellate cells apoptosis partially by regulating autophagy-dependent AKT signaling pathway activation. PMID: 25600591
    20. TRPV1/4 channels are potent therapeutic targets for site-specific vasodilation in the kidney PMID: 25069877
    21. Data suggest that age-related increases in transient receptor potential vanilloid type 4 (TRPV4) expression in the brain and spinal cord may provide information for investigating the pathogenesis of age-related neurodegenerative diseases. PMID: 24917364
    22. We examined the role of TRPV4 channels in the development of high-amplitude spontaneous Ca(2) oscillations in astrocyte endfeet and the inversion of neurovascular coupling after subarachnoid hemorrhage. PMID: 25366609
    23. activation of TRPV4 channels mediates flow-induced NO production in thick ascending limb PMID: 24966090
    24. TRPV4, TRPC1, and TRPP2 contribute to the ion permeation pore of the channels PMID: 25114176
    25. This study provided the first evidence for TRPC1 and TRPV4 channels as potential contributors to mechanosensation in the atrial volume receptors. PMID: 24631674
    26. Demonstrate increased TRPV4 expression in the urothelium following stress and that TRPV4 blockade ameliorates stress-induced bladder dysfunction. PMID: 24965792
    27. Results show that TRPV4 activation in the intestinal epithelium caused epithelial hyperpermeability in response to NSAID-induced arachidonic acid metabolites and contributed to NSAID-induced intestinal damage. PMID: 24789205
    28. ASMC proliferation in response to TRPV4 activity. PMID: 24392954
    29. The results of the present study suggest that endothelial TRPV4 channels are present in the endothelium of the rat pulmonary artery and their activation causes endothelium-dependent relaxation involving NO and EDHF. PMID: 24075884
    30. our results provide the first evidence that glial cell-expressed TRPV4 is a potential key factor responsible for infrasound-induced neuronal impairment PMID: 24002225
    31. These data show, therefore, a particular role of IL-17 in mechanical hyperalgesia, and they suggest that this effect is linked to an activation and upregulation of TRPV4. PMID: 23147107
    32. TRPV4 mediates Ca(2+) influx and substance P release in dorsal root ganglion. PMID: 22762361
    33. The mechanosensitive ion channel, TRPV4, regulates cardiac fibroblast differentiation to myofibroblasts by integrating signals from TGF-beta1 and mechanical factors. PMID: 23142541
    34. the functional status of TRPV4, which underlies mechanosensitive Ca(2 ) signaling in collecting duct cells, inversely correlates with renal cystogenesis in autosomal recessive polycystic kidney disease. PMID: 23411787
    35. Coimmunoprecipitation experiments of transfected cells revealed that rat TRPV4 and tubulin beta 5 associated together in a complex. PMID: 22309793
    36. TRPV4 protein was predominantly located in the nucleus of cultured neonatal myocytes PMID: 23027348
    37. Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling PMID: 23288842
    38. Trpv4 expression in female Wistar rats varied with postnatal age, tissue (urothelium, detrusor, or whole bladder), and duration (4-h, 48-h, or chronic) of cyclophosphamide-induced cystitis. PMID: 22865090
    39. show that TRPV4 channels are involved in ischemia-induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult PMID: 22761937
    40. Relevance of the TRPV4-RyR2 signaling pathway under hypoxic conditions that may lead to pulmonary hypertension. PMID: 22962011
    41. TRPV1 is implicated in rat pulmonary arterial smooth muscle cells migration. PMID: 22820913
    42. It was shown that both retinal and vestibular ganglion cells can be stimulated reproducibly by lasers and that neuronal responses are driven through transient receptor potential vanilloid 4 channels. PMID: 22442563
    43. In this rat model of inflammation, TRPV-4 is expressed and functional in trigeminal ganglion neurons and synovial cells PMID: 22184014
    44. TRPV4 was the only member of the TRPV and TRPM subfamilies upregulated in PAs of chronic hypoxic rats. PMID: 22207590
    45. Activation of TRPV4 in the bladder, probably urothelium, facilitates the micturition reflex by activation of the mechanosensitive, Cap-insensitive C-fibers of the primary bladder afferents in rats. PMID: 22038643
    46. aberrant TRPV4 activity may lead to some types of pathology of sensory and motor nerves PMID: 22187434
    47. activation of TRPV4 within the meninges produces afferent nociceptive signaling from the head that may contribute to migraine headache. PMID: 22049072
    48. our data suggested that NF-kappaB could be involved in TRPV4-NO pathway in CCD-induced thermal hyperalgesia. PMID: 21356247
    49. Pharmacological Trpv4 activation enhanced cerebral arteriogenesis, pinpointing Trpv4 as a possible candidate for the development of new therapeutic concepts. PMID: 21316269
    50. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. PMID: 20956320

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  • 亚细胞定位：
    Cell membrane. Apical cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Cell projection, cilium.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV4 sub-subfamily
  • 组织特异性：
    Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia.
  • 数据库链接：

    KEGG: rno:66026

    STRING: 10116.ENSRNOP00000001586

    UniGene: Rn.64508

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