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  4. Recombinant Rat Transient receptor potential cation channel subfamily M member 4 (Trpm4), partial

Recombinant Rat Transient receptor potential cation channel subfamily M member 4 (Trpm4), partial

  • 中文名称：
    大鼠Trpm4重组蛋白
  • 货号：
    CSB-YP880659RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Trpm4重组蛋白
  • 货号：
    CSB-EP880659RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Trpm4重组蛋白
  • 货号：
    CSB-EP880659RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Trpm4重组蛋白
  • 货号：
    CSB-BP880659RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Trpm4重组蛋白
  • 货号：
    CSB-MP880659RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trpm4
  • Uniprot No.：
    Q9ESQ5
  • 别名：
    Trpm4; Ltrpc4; Transient receptor potential cation channel subfamily M member 4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; MLS2s; Melastatin-like 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells. Plays a role in keratinocyte differentiation.
  • 基因功能参考文献：
    1. Rat dental pulp stem cells have stem cell characteristics and functional TRPM4 channels that are required for proliferation and survival. These data suggest that the shape and frequency of intracellular Ca(2+) signals may mediate stem cell proliferation and survival. PMID: 28758259
    2. TRPM4 is involved in hypoxia-reoxygenation injury in the cardiomyocytes. PMID: 25836769
    3. Data indicate the acidic amino acids are required for the proper activation of transient receptor potential (TRP) channel melastatin subfamily member 4 (TRPM4) by calcium. PMID: 25378404
    4. Inhibition of TRPM4 Channels Reduces Pressure-Induced Vasoconstriction of Parenchymal Arterioles. PMID: 25099756
    5. ENaC and TRPM4 interact in rat posterior cerebral arteries and play important roles in the pressure-induced myogenic response. PMID: 24391909
    6. These findings suggest an inhibitory role for TRPM4 on osteogenesis while it appears to be required for adipogenesis. PMID: 23081848
    7. TRPM4 channels are critical regulators of rat detrusor smooth muscle excitability and contractility PMID: 23283997
    8. Endogenous Ca(2+) buffer proteins play a critical role in maintaining TRPM4 channel activity in native cerebral artery smooth muscle cells. PMID: 22153976
    9. These channels may play an important role in determining the distinct firing properties of vasopressin neurones in the supraoptic nucleus. PMID: 21848647
    10. Data demonstrate that TRPM4 is an important regulator of smooth muscle cell membrane depolarization and arterial constriction in response to intraluminal pressure. PMID: 20826763
    11. TRPM4 channels are activated by intracellular divalent calcium ion (Ca2+) signaling in cerebral artery smooth muscle cells. PMID: 20427713
    12. two rTRPM4 isoforms, rTRPM4a and rTRPM4b, were cloned and characterized. PMID: 19945433
    13. Activation of TRPM4-dependent currents contributed to myogenic vasoconstriction of cerebral arteries. PMID: 15472118
    14. insulin-secreting cells of the pancreatic beta-cell line INS-1 natively express TRPM4 proteins and generate large depolarizing membrane currents in response to increased intracellular calcium PMID: 16806463
    15. may contribute to the transient inward current implicated in delayed-after-depolarizations observed during [Ca(2+)] overload of cardiomyocytes. PMID: 16966582
    16. Protein kinase C-dependent regulation of TRPM4 activity contributes to the control of cerebral artery myogenic tone. PMID: 17293488
    17. In vivo suppression of TRPM4 decreases cerebral artery myogenic constrictions and impairs autoregulation, thus implicating TRPM4 channels and myogenic constriction as major contributors to cerebral blood flow regulation in the living animal. PMID: 17585083
    18. Depolarizing currents generated by TRPM4 are an important component in the control of intracellular Ca(2+) signals necessary for insulin secretion and perhaps glucagon from alpha-cells. PMID: 19063936
    19. in vivo gene suppression in rats treated with Trpm4 antisense or in Trpm4(-/-) mice preserved capillary structural integrity, eliminated secondary hemorrhage, yielded a 3x to 5x reduction in lesion volume and produced improvement in neurological function PMID: 19169264

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus.; [Isoform 2]: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM4 sub-subfamily
  • 组织特异性：
    Isoform 1 is highly expressed in the testis with a moderate expression in the brain, spleen and thymus. Isoform 2 is only expressed in the brain and spleen.
  • 数据库链接：

    KEGG: rno:171143

    STRING: 10116.ENSRNOP00000041387

    UniGene: Rn.205004

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