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  4. Recombinant Rat Transcription factor A, mitochondrial (Tfam)

Recombinant Rat Transcription factor A, mitochondrial (Tfam)

  • 中文名称：
    大鼠Tfam重组蛋白
  • 货号：
    CSB-YP023413RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Tfam重组蛋白
  • 货号：
    CSB-EP023413RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Tfam重组蛋白
  • 货号：
    CSB-EP023413RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Tfam重组蛋白
  • 货号：
    CSB-BP023413RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Tfam重组蛋白
  • 货号：
    CSB-MP023413RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tfam
  • Uniprot No.：
    Q91ZW1
  • 别名：
    Tfam; Transcription factor A; mitochondrial; mtTFA
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    43-244
  • 氨基酸序列
    SSLGNYPK KPMSSYLRFS TEQLPKFKAK HPDAKVSELI RKIAAMWREL PEAEKKVYEA DFKAEWKVYK EAVSKYKEQL TPSQLMGLEK EARQKRLKKK AQIKRRELIL LGKPKRPRSA YNIYVSESFQ EAKDESAQGK LKLVNQAWKN LSHDEKQAYI QLAKDDRIRY DNEMKSWEEQ MAEVGRSDLI RRSVKRPPGD ISEN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.; May also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis.
  • 基因功能参考文献：
    1. these results indicate that defect mitochondrial biogenesis in RVLM neurons entailing redox-sensitive and IL-1beta-dependent suppression of TFAM because of the increase in the formation of Keap1/Nrf2 complex, reductions in nuclear translocation of the activated Nrf2 and its binding to the Tfam gene promoter may underlie hypertension developed under the LPS-induced systemic inflammation PMID: 27223823
    2. Following skeletal muscle denervation, import of Tfam into the mitochondrion is the critical point of regulation for this protein. PMID: 26063705
    3. The modulation of TFAM expression, TFAM-binding to mtDNA and mtDNA content with aging and CR showed a trend shared by the skeletal muscle and liver, but not by the frontal cortex counterpart. PMID: 24631828
    4. An age-related decrease in mitochondrial DNA (mtDNA) content and mitochondrial transcription factor A (TFAM) amount, fully prevented by calorie restriction. PMID: 24058615
    5. subnormal membrane transport to systems in diabetes impair the transfer of TFAM into the mitochondria, and decreased TFAM-mtDNA binding that results in subnormal mitochondria transcription. PMID: 23255365
    6. TFAM can act as a damage-associated molecular pattern and may contribute to the initiation of inflammatory responses in hemorrhagic shock. PMID: 22469910
    7. investigation of role of expression of mitochondrial transcription factor A in a model for development of presbycusis (age-related hearing loss) PMID: 21575134
    8. Downregulation of Tfam and mtDNA copy number during mammalian spermatogenesis PMID: 11668394
    9. reduced binding activity of mtTFA to the D-loop region in the hearts of diabetic rats may contribute to decreased mitochondrial protein synthesis PMID: 11882497
    10. results describe the post-translational modifications of mitochondrial transcription factor A (TFAM) in 6- and 28-month-old rat liver PMID: 12535660
    11. Results indicate that an impairment of mitochondrial transcription factor A binding to the promoter sequence has a key role in abnormal mitochondrial gene expression, which might explain the mitochondrial dysfunction found in diabetic heart. PMID: 15126286
    12. Expression of mtTFA is upregulated in intimal vascular smooth muscle cells of injured rat carotid artery, and suppression of mtTFA expression by antisense oligodeoxynucleotides can attenuate intimal thickening after balloon injury. PMID: 15585199
    13. novel redox regulation of NRF-1 phosphorylation and nuclear translocation by phosphatidylinositol 3,4,5-triphosphate kinase/Akt signaling in controlling Tfam induction by an anti-oxidant pro-survival network PMID: 16230352
    14. in a physiological condition such as embryonic development the TFAM levels change in order to regulate the transcriptional activity of mtDNA PMID: 16543724
    15. protein abundant in liver cells that recognizes DNA adducts induced by the chemical carcinogen N-acetoxy-acetylaminofluorene is identified as TFAM. Its high affinity for DNA damaged by AAAFonfirmed. PMID: 17143337
    16. TFAM overexpression protected cell function against the damage induced by high glucose in cardiomyocytes PMID: 19060297
    17. The genetic control by the beta cell-specific factor Insulin promoter factor 1 of the ubiquitous gene mitochondrial factor A maintains beta cell mitochondrial DNA vital for ATP production and normal glucose-stimulated insulin secretion. PMID: 19656489

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  • 亚细胞定位：
    [Isoform Mitochondrial]: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.; [Isoform Nuclear]: Nucleus.
  • 组织特异性：
    The mitochondrial isoform is widely expressed while the nuclear isoform is testis-specific.
  • 数据库链接：

    KEGG: rno:83474

    STRING: 10116.ENSRNOP00000000753

    UniGene: Rn.18266

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