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  4. Recombinant Rat Telomerase reverse transcriptase (Tert), partial

Recombinant Rat Telomerase reverse transcriptase (Tert), partial

  • 中文名称：
    大鼠Tert重组蛋白
  • 货号：
    CSB-YP023391RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Tert重组蛋白
  • 货号：
    CSB-EP023391RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Tert重组蛋白
  • 货号：
    CSB-EP023391RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Tert重组蛋白
  • 货号：
    CSB-BP023391RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Tert重组蛋白
  • 货号：
    CSB-MP023391RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tert
  • Uniprot No.：
    Q673L6
  • 别名：
    Tert; Telomerase reverse transcriptase; EC 2.7.7.49; Telomerase catalytic subunit
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
  • 基因功能参考文献：
    1. Curcumin may be a good candidate to improve lifespan of rADSCs through promoting TERT gene expression. PMID: 29017189
    2. TERT was expressed in the basilar membranes during the first postnatal week. In vitro, TERT expression in progenitor cells reached a maximum at day 4 after culture and decreased as the culture time prolonged or the cell passage number increased. These results led us to hypothesize that TERT may be involved in the development of the cochlea and in maintaining the proliferation ability of progenitor cells. PMID: 29436610
    3. Proliferation rate, telomerase activity, telomere length, and differentiation to cholinergic neuron-like cells (CNLCs) were observed to increase. Though, the expression level of telomerase reverse transcriptase gene increased, but CTC1 and TEN1 genes from Ctc1-Stn1-Ten1 complex encoding proteins with regulatory function significantly decreased PMID: 27251157
    4. Histone deacetylase inhibition induces TERT transcription and promoter activation. At the protein level in contrast, HDAC inhibition decreases TERT protein abundance through enhanced degradation, which decreases telomerase activity and induces senescence. PMID: 26505494
    5. These findings suggest that cardiac telomerase activity may play an important role in the maintenance of normal cardiac function. PMID: 25662949
    6. TERT is a genome-independent source of mature miRNA, and the changes in telomerase activity can significantly influence the level of miRNA in cardiomyocytes. PMID: 25156787
    7. Elevated Hcy but not hypertension was related to TERT DNA hypomethylation and reduced mRNA level, thus contributing to the shortening of LTL hypertension. PMID: 24882549
    8. These data suggest that TERT plays a neuroprotective role via anti-apoptosis in neurons after oxygen and glucose deprivation PMID: 23968592
    9. hyperglycemia and hyperinsulinemia stimulate telomerase activity and the proliferation of vascular smooth muscle cells. PMID: 23450462
    10. Cadmium may contribute to carcinogenesis by activating telomerase, and overexpressing the mRNAs of TERT, c-myc and p53, and causing apoptosis of normal hepatocytes. PMID: 21181359
    11. TERT might function as an anti-apoptotic protein by inhibiting activation of caspase-3. PMID: 22446191
    12. Telomerase activation is present in ovary antral granulosa cells. PMID: 21141566
    13. The expression of TERT significantly increases after electrical stimulation of the cerebellar fastigial nucleus. TERT may bind to Bax and inhibit Bax-mediated apoptosis. PMID: 21914402
    14. p53 and telomerase control rat myocardial tissue response to hypoxia and ageing PMID: 22073357
    15. A role is found for telomerase in early cell senescence of olfactory ensheathing glia and protection from oxidative damage. PMID: 20736004
    16. TERT could be induced by hypoxia ischemia brain damage in neonatal rats, and might have a protective role in regulating cell apoptosis. PMID: 20540267
    17. Vascular injury induces de novo expression of TERT in intimal smooth muscle cells via activation of nuclear factor kappa B and upregulation of c-Myc,leading to hyperplasia. PMID: 20864668
    18. This study suggested that TERT deficiency can predispose to the development of stroke in an experimental model of this disease. PMID: 20564349
    19. TERT translocation might be more useful than TERT expression level and telomerase activity in predicting the progression of HCC. PMID: 20353272
    20. TGF-beta triggers cell cycle arrest and death by a mechanism involving telomerase deregulation of telomere maintenance. PMID: 20138964
    21. Improving insulin sensitivity via activation of PPAR-gamma increases telomerase activity in the heart of OLETF rats. PMID: 19855065
    22. Results indicate that, in rat lung epithelial cells, in vitro transformation and acquisition of tumorigenic properties can occur even if telomere length is still decreasing and telomerase activity remains downregulated. PMID: 12729792
    23. telomerase, withdraws by a mechanism at TERT gene transcription level involving MAP kinase signalling while cells cease proliferation and undergo differentiation PMID: 16248892
    24. The results showed that inhibition of induced telomerase increased alpha-smooth muscle actin expression, an indicator of myofibroblast differentiation. PMID: 16424384

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  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body.
  • 蛋白家族：
    Reverse transcriptase family, Telomerase subfamily
  • 组织特异性：
    Isoform 1 and isoform 2 expressed in thymus, liver, spleen, lung, kidney and testis. High level of inactive isoform 3 in adult hippocampus, low level in heart, cortex and cerebellum.
  • 数据库链接：

    KEGG: rno:301965

    STRING: 10116.ENSRNOP00000022683

    UniGene: Rn.48802

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