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  4. Recombinant Rat TSC22 domain family protein 3 (Tsc22d3)

Recombinant Rat TSC22 domain family protein 3 (Tsc22d3)

  • 中文名称：
    大鼠Tsc22d3重组蛋白
  • 货号：
    CSB-YP866823RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Tsc22d3重组蛋白
  • 货号：
    CSB-EP866823RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Tsc22d3重组蛋白
  • 货号：
    CSB-EP866823RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Tsc22d3重组蛋白
  • 货号：
    CSB-BP866823RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Tsc22d3重组蛋白
  • 货号：
    CSB-MP866823RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tsc22d3
  • Uniprot No.：
    Q9EQZ1
  • 别名：
    Tsc22d3; Dsipi; Gilz; TSC22 domain family protein 3; Glucocorticoid-induced leucine zipper protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-134
  • 氨基酸序列
    MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAL DNKIEQAMDL VKNHLMYAVR EEVEVLKEQI RELVEKNSQL ERENTLLKTL ASPEQLEKFQ SRLSPEEPAP EAPETPEAPG GSAV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
  • 基因功能参考文献：
    1. Overexpression of GILZ by OE-GILZ-rLV transduction protected the retina from light-induced cellular damage by activating antiapoptotic pathways. PMID: 28728173
    2. GILZ may be sensitive to the elevated expression of GC in septic muscle, promoting the expression and activation of GR involved in GC/GR-mediated proteolysis in septic skeletal muscle. PMID: 25299205
    3. Our data demonstrate GILZ induction in cardiomyocytes both in vivo and in vitro by glucocorticoids, pointing to H9c2(2-1) cells as a valid model for studying the biological function of GILZ in cardiomyocytes. PMID: 23090754
    4. the delta sleep-inducing peptide effect on c-Fos gene expression might be mediated by NMDA-receptors. PMID: 22094385
    5. GILZ has an important role not only in adjusting adaptive responses to hypoxia by negatively regulating the activation of macrophages and the expression of proinflammatory cytokines PMID: 22124125
    6. a role in blocking excitatory effects of glutamate on rat brain neurons PMID: 12459854
    7. Induction of GILZ mRNA may play a permissive role in the enhancement of the early and/or late responses; these effects may be necessary for a full response but do not by themselves promote early changes in urinary Na(+) and K(+) excretion. PMID: 12707381
    8. multiple GILZ isoforms are expressed in most cells and tissues and that these play distinct roles in regulating proliferation and ion transport. PMID: 17956870
    9. In PC12 cells, dexamethasone treatment leads to a progressive increase of GILZ mRNA expression levels via a glucocorticoid receptor-dependent mechanism. PMID: 18643788

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TSC-22/Dip/Bun family
  • 数据库链接：

    KEGG: rno:83514

    STRING: 10116.ENSRNOP00000051018

    UniGene: Rn.21970

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