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  4. Recombinant Rat Solute carrier family 22 member 1 (Slc22a1), partial

Recombinant Rat Solute carrier family 22 member 1 (Slc22a1), partial

  • 中文名称：
    大鼠Slc22a1重组蛋白
  • 货号：
    CSB-YP717352RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc22a1重组蛋白
  • 货号：
    CSB-EP717352RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc22a1重组蛋白
  • 货号：
    CSB-EP717352RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc22a1重组蛋白
  • 货号：
    CSB-BP717352RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc22a1重组蛋白
  • 货号：
    CSB-MP717352RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc22a1
  • Uniprot No.：
    Q63089
  • 别名：
    Slc22a1; Oct1; Solute carrier family 22 member 1; Organic cation transporter 1; rOCT1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
  • 基因功能参考文献：
    1. Protein and mRNA expression levels of Oat1, Oat3, Oct1, and Oct2 were significantly decreased in adenine-induced chronic renal failure rats. PMID: 23280877
    2. Hnf4alpha occupies Oat1, Oat3, and Oct1 proximal promoters in the in vivo differentiating rat kidney. PMID: 22808265
    3. A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1. PMID: 22810231
    4. The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. PMID: 21896487
    5. Findings suggest that Oct-1 as a co-factor might directly or indirectly collaborate in a cell-type-specific manner with the intronic enhancer in the amelogenin gene. PMID: 20044581
    6. OCT-1 binds within DHS3 to silence Fshr transcription, an activity that involves members of the GATA family PMID: 15817654
    7. Purification and reconstitution of functional active rOCT1 protein PMID: 16142924
    8. Effects of the sulfhydryl reagent methylmethanethiosulfonate (MMTS) on functions of organic cation transporters (OCTs) were investigated. PMID: 17567940
    9. These results suggest that the saturable component in the hepatic uptake of these cationic compounds may be mediated mainly by hOCT1/rOct1. PMID: 17701831
    10. During endotoxemia NO, produced by iNOS, is responsible for a down-regulation of the renal influx carriers, Oct1 and Oct2. PMID: 18313662
    11. Five amino acids in the innermost cavity of the substrate binding cleft of Roct1 interact with extracellular and intracellular corticosterone. PMID: 19435783

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Note=Within sinusoidal membrane of hepatocytes.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Expressed in kidney, kidney cortex, kidney medulla, liver, intestine and colon. Expressed in proximal tubules in kidney, hepatocytes in liver and enterocytes of villi and crypts in smallintestine. Expressed throughout the liver lobuli. Expressed in hepato
  • 数据库链接：

    KEGG: rno:24904

    STRING: 10116.ENSRNOP00000022254

    UniGene: Rn.11186

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