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  4. Recombinant Rat Solute carrier family 2, facilitated glucose transporter member 5 (Slc2a5), partial

Recombinant Rat Solute carrier family 2, facilitated glucose transporter member 5 (Slc2a5), partial

  • 中文名称：
    大鼠Slc2a5重组蛋白
  • 货号：
    CSB-YP331824RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc2a5重组蛋白
  • 货号：
    CSB-EP331824RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc2a5重组蛋白
  • 货号：
    CSB-EP331824RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc2a5重组蛋白
  • 货号：
    CSB-BP331824RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc2a5重组蛋白
  • 货号：
    CSB-MP331824RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc2a5
  • Uniprot No.：
    P43427
  • 别名：
    Slc2a5; Glut5; Solute carrier family 2; facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5; small intestine; GLUT-5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
  • 基因功能参考文献：
    1. crystal structures of GLUT5 from Rattus norvegicus and Bos taurus in open outward- and open inward-facing conformations, respectively PMID: 26416735
    2. investigation of influence of dietary carbohydrates on expression of Glut5 in small intestine: Glut5 mRNA increased with fructose perfusion and age, a pattern that matched that of Pol II binding and histone H3 acetylation at Glut5 promoter PMID: 21222652
    3. insulin is capable of increasing the abundance and functional activity of GLUT5 in skeletal muscle cells, most likely mediated via activation of the GLUT5 promoter PMID: 12914929
    4. Short-term fructose feeding increases the expression of glucose transporter 5 in both young and aging adult rats. Increased brain expression of glucose transporter 5 is important in the role of fructose as an alternative energy source. PMID: 16581195
    5. T3 and fructose coordinately enhance expression of Slc2a5 gene in the small intestine during weaning period. PMID: 17485832
    6. Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function. PMID: 17947353
    7. The essential role of chloride and fructose absorbing Slc2a5 is reported. PMID: 18496516
    8. The expression and metabolism of GLUT5 during the postnatal developmental process are reported. PMID: 18556366

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma.
  • 蛋白家族：
    Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
  • 组织特异性：
    Detected in jejunum. Detected in kidney, skeletal muscle, brain and adipose tissue (at protein level). Detected in small intestine and in kidney, and at much lower levels in brain. Detected in enterocytes in duodenum, jejunum, and ileum.
  • 数据库链接：

    KEGG: rno:65197

    STRING: 10116.ENSRNOP00000024054

    UniGene: Rn.10900

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