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  4. Recombinant Rat Sodium/hydrogen exchanger 2 (Slc9a2), partial

Recombinant Rat Sodium/hydrogen exchanger 2 (Slc9a2), partial

  • 中文名称：
    大鼠Slc9a2重组蛋白
  • 货号：
    CSB-YP021729RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc9a2重组蛋白
  • 货号：
    CSB-EP021729RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc9a2重组蛋白
  • 货号：
    CSB-EP021729RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc9a2重组蛋白
  • 货号：
    CSB-BP021729RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc9a2重组蛋白
  • 货号：
    CSB-MP021729RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc9a2
  • Uniprot No.：
    P48763
  • 别名：
    Slc9a2; Nhe2; Sodium/hydrogen exchanger 2; H7; Na(+)/H(+) exchanger 2; NHE-2; Solute carrier family 9 member 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
  • 基因功能参考文献：
    1. Results provide evidence that NHE2 and AQP2 work in coordination as part of the cellular device that regulates collecting duct cell cycle progression. PMID: 27191152
    2. These findings demonstrate suppression of NHE-2 expression on the brush borders in the colonic epithelial cells which is regulated transcriptionally. PMID: 28493993
    3. observations suggest that the butyrate activation of NHE2 would be a potential target to control UC-associated diarrhea PMID: 26350456
    4. mediates bicarbonate reabsorption in nephron PMID: 11704563
    5. increases of two- to threefold in protein and mRNA abundance of NHE2 and NHE3 were observed in ileal regions distal to the anastomosis of proximal small bowel resected rats PMID: 12223358
    6. renal Na+/H+ exchanger-NHE3 and NHE2 levels are regulated by angiotensin-II PMID: 15238256
    7. NHEs are intraterminal pH regulators on GABAergic presynaptic nerve terminals, and the NHE-mediated regulation of pH(i)might play an important role in neuronal excitability by increasing inhibitory tones. PMID: 17018119
    8. NHE2/NHE3 chimeric proteins demonstrate that the Na(+)-removal response element resides predominantly in the NHE3 cytoplasmic tail and is distinct from the acidification response sequence of NHE2. PMID: 17303069
    9. We conclude that the mechanism of basal control of rat NHE2 gene promoter activity is different in the renal and intestinal epithelium, with Sp3 being the major transcriptional activator of NHE2 gene transcription in the intestinal epithelial cells. PMID: 17379926

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 组织特异性：
    Predominantly in small intestine, colon, and stomach, with much lower levels in skeletal muscle, kidney, brain, testis, uterus, heart and lung.
  • 数据库链接：

    KEGG: rno:24783

    STRING: 10116.ENSRNOP00000021270

    UniGene: Rn.11047

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