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  4. Recombinant Rat Sodium channel protein type 5 subunit alpha (Scn5a), partial

Recombinant Rat Sodium channel protein type 5 subunit alpha (Scn5a), partial

  • 中文名称：
    大鼠Scn5a重组蛋白
  • 货号：
    CSB-YP020843RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Scn5a重组蛋白
  • 货号：
    CSB-EP020843RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Scn5a重组蛋白
  • 货号：
    CSB-EP020843RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Scn5a重组蛋白
  • 货号：
    CSB-BP020843RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Scn5a重组蛋白
  • 货号：
    CSB-MP020843RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Scn5a
  • Uniprot No.：
    P15389
  • 别名：
    Scn5a; Sodium channel protein type 5 subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
  • 基因功能参考文献：
    1. The failing heart has ~30% lower SCN5A levels. PMID: 28205593
    2. The upregulation of PKC-gamma may directly or indirectly downregulate the expression of Nav1.5 isoforms in spared nerve injury rat models, which may further involve in the pathological process of neuropathic pain. PMID: 29393394
    3. Clinically relevant cardiotoxicity of domperidone and metoclopramide corresponds to a rather potent and local anesthetic-like inhibition of cardiac Na channels including Nav1.5. PMID: 27861438
    4. Nav1.5 N-terminal domain binding to alpha1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels PMID: 26786162
    5. Scn5a is expressed in jejunum and colon smooth muscle and it contributes to smooth muscle electrophysiology. PMID: 26459913
    6. UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein levels via the ubiquitin-proteasome pathway. PMID: 26059563
    7. Flecainide (1 mum) rescues the RyR2-P2328S atrial arrhythmogenic phenotype by restoring compromised INa and lambda, changes recently attributed to increased sarcoplasmic reticular Ca(2+) release. PMID: 25850710
    8. As in the brain, epilepsy was associated with an enhanced expression of the neuronal isoform NaV1.1 in cardiomyocyte. Epilepsy was also associated with a lower INa activation threshold resulting in increased cell excitability. PMID: 26067667
    9. Provocation of an autoimmune response against NaV1.5 induces cardiac conduction defects. PMID: 23684688
    10. The voltage gated sodium channel Na(v)1.5, which is responsible for initiation of the action potential, was found to interact with perinexal Cx43 but not with ZO-1. PMID: 22811280
    11. Nav1.5 (rN1) has a newly identified exon for alternative splicing that is differentfrom rat heart and is more widely expressed in rat brain than previously thought. PMID: 22331407
    12. Na(v)1.5-dependent increase in Na(+influx activates CaMKII, which in turn phosphorylates Na(v)1.5, further promoting Na(+) influx. Pharmacological inhibition of either CaMKII or Na(v)1.5 ameliorates cardiac dysfunction caused by excessive Na(+) influx. PMID: 21677263
    13. These results suggest that Nav1.5 channels in human and rat brains are encoded by new variants of Nav1.5/SCN5A and Nav1.5 is more widely distributed and expressed than previously thought. PMID: 19376164
    14. Altering the oxidized to reduced NAD(H) balance can activate mitochondrial reactive oxygen species production, leading to reduced I(Na) via SCN5A PMID: 20724705
    15. In cultured adult rat skeletal muscle fibers, an increase of the Na(V)1.5 channel type was observed. These channels exhibited increased activation time constant (tau(m)) and reduced conductance. PMID: 20517693
    16. novel isoforms of Na(v)1.8 and Na(v)1.5 are each generated by alternative splicing at CAG/CAG motifs, which result in the absence or presence of predicted glutamine residues within the interdomain cytoplasmic loop IDII/III PMID: 15047701
    17. Nav1.5 is expressed in gastric epithelial cells and function as growth modulators. PMID: 16331678
    18. Na(V)1.5 was abundant in the atrial & ventricular myocardium & the left bundle branch, but absent in the open node, penetrating AV bundle, AV ring bundle, & common bundle. A reduced level was found in the inferior nodal extension & transitional zone. PMID: 16966585
    19. Skeletal myotubes adopt a cardiac-like phenotype in cell culture conditions and that the expression of Na(v)1.5 acts as an underlying molecular mechanism. PMID: 17900547
    20. ANG II can decrease scn5a transcription and current. This effect appears to be through production of H(2)O(2) resulting in NF-kappaB binding to the Na(+) channel promoter. PMID: 18032528
    21. PKP2 associates with Na(V)1.5, and that knockdown of PKP2 expression alters the properties of the sodium current, and the velocity of action potential propagation in cultured cardiomyocytes. PMID: 19661460
    22. Mutations of GPD1-L may downregulate Na(v)1.5 by altering the oxidized to reduced NAD(H) balance. PMID: 19745168

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cell membrane, sarcolemma, T-tubule.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily
  • 组织特异性：
    Strongly expressed in the heart. Also expressed in adult and fetal brain, spinal cord, testis, and at moderate levels in kidney, adrenal gland, lung, skeletal muscle, spleen, stomach and bladder. Isoform 2 is expressed in brain.
  • 数据库链接：

    KEGG: rno:25665

    STRING: 10116.ENSRNOP00000060180

    UniGene: Rn.32074

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