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  4. Recombinant Rat Sodium channel protein type 2 subunit alpha (Scn2a), partial

Recombinant Rat Sodium channel protein type 2 subunit alpha (Scn2a), partial

  • 中文名称：
    大鼠Scn2a重组蛋白
  • 货号：
    CSB-YP020836RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Scn2a重组蛋白
  • 货号：
    CSB-EP020836RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Scn2a重组蛋白
  • 货号：
    CSB-EP020836RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Scn2a重组蛋白
  • 货号：
    CSB-BP020836RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Scn2a重组蛋白
  • 货号：
    CSB-MP020836RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Scn2a
  • Uniprot No.：
    P04775
  • 别名：
    Scn2a; Scn2a1Sodium channel protein type 2 subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory.
  • 基因功能参考文献：
    1. The Nav1.2 are highly expressed in axon terminals in central hilus compared to stratum radiatum and in dendrites and spines in stratum radiatum compared to central hilus . PMID: 28758202
    2. Knockdown of Nav1.2 channels in pre-oligodendrocyte alters their morphology, reduces axon-oligodendrocyte interactions and impairs myelination. PMID: 28916793
    3. Here, the authors show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of NaV1.2 channels increases sodium current. PMID: 28029095
    4. The polarity of (Ca(2+))2-CaMC relative to the IQ motif of NaV1.2 was opposite to that seen in apo CaMC-Nav1.2IQp (2KXW), revealing that CaMC recognizes nested, anti-parallel sites in Nav1.2IQp. (CaMC is C-domain residues of CaM, calmodulin). PMID: 28343066
    5. miR-9 suppressed the trafficking of Nav1.1/Nav1.2 from cytoplasm to cell membrane. miR-9 overexpression inhibited Navbeta2 expression by targeting its coding sequence domain. PMID: 26259688
    6. Fibroblast growth factor 12 is a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in the rat brain. PMID: 25724910
    7. In NaV1.2, Cys910 is disulfide-bonded to Cys918 and Cys912. PMID: 26039939
    8. Reciprocal regulation of phosphorylation and MeArg of Nav1.2 may underlie changes in neuronal Nav channel function in response to seizures and also contribute to physiological modulation of neuronal excitability. PMID: 24737319
    9. In the dorsal horn of the developing rat, Na(v) isoforms are developmentally regulated at the mRNA level in a subtype-specific manner, as Na(v)1.2 and Na(v)1.3 decreased significantly from P3 to adulthood, while Na(v)1.1 was upregulated during this period PMID: 23219908
    10. NaV1.2 channels are expressed in vascular smooth muscle cells where they are involved in muscle contraction. PMID: 23364266
    11. Lipid modifications are capable of altering the gating and pharmacological properties of rNav1.2a. PMID: 22123950
    12. Data demonstrate that the two N-terminal alternatively spliced FGF14 variants, FGF14-1a and FGF14-1b, differentially regulate currents produced by Nav1.2 and Nav1.6 channels. PMID: 19465131
    13. The wedge-shaped CssIV inserts between the IIS1-S2 and IIS3-S4 loops of rat brain sodium channels, placing key amino acid residues in position to interact with binding partners in these extracellular loops. PMID: 21795675
    14. The ability to manipulate mu-conopeptide KIIIA's affinity and efficacy, as well as its capacity to interfere with subsequent tetrodotoxin binding, greatly expands its scope as a reagent for probing sodium channel structure and function. PMID: 20459109
    15. the TTX-sensitive Na(v)1.2 isoform, together with the Na(+)/Ca(2+) exchanger, contributes to the contractile response of aortic myocytes at physiological range of membrane depolarizatio PMID: 19809503
    16. Helix-stabilizing effects of the pentapeptide KIFMK and its related peptides on the sodium channel inactivation gate peptides PMID: 11892850
    17. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG PMID: 12036953
    18. expression of a soluble Nav1.2II-III linker protein led to the disorganization of endogenous sodium channels; results indicate this motif may play a fundamental role in controlling electrical excitability during development and plasticity [Nav1.2] PMID: 12829783
    19. Oscillatory properties of the voltage-gated sodium channel may contribute to the sub-threshold membrane-potential oscillation and epileptic discharges in a single neuron. PMID: 16596442
    20. NaV1.2 channels were predominately localized in unmyelinated fibers in the cortex, hippocampus, spinal cord and hypothalamus. PMID: 16815341
    21. The pathogenic mechanism of benign familial neonatal-infantile seizures (BFNIS) mutations is neuronal hyperexcitability caused by increased Na(v)1.2 Na+ current, as shown in functional studies of rat pups. PMID: 17021166
    22. AKAP15 directly interacts with Na(v)1.2a channels via the intracellular loop between domains I and II. PMID: 17360357
    23. Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. PMID: 19221510
    24. Proteolysis results in loss of full-length alpha-subunits and the creation of fragments comprising all domains of the channel that retain interaction even after proteolysis. PMID: 19692609

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, Nav1.2/SCN2A subfamily
  • 组织特异性：
    Expressed in brain (at protein level). Expressed in cerebellar granule neurons (at protein level).
  • 数据库链接：

    KEGG: rno:24766

    STRING: 10116.ENSRNOP00000007069

    UniGene: Rn.89192

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