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  4. Recombinant Rat Sodium/calcium exchanger 2 (Slc8a2), partial

Recombinant Rat Sodium/calcium exchanger 2 (Slc8a2), partial

  • 中文名称：
    大鼠Slc8a2重组蛋白
  • 货号：
    CSB-YP021724RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc8a2重组蛋白
  • 货号：
    CSB-EP021724RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc8a2重组蛋白
  • 货号：
    CSB-EP021724RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc8a2重组蛋白
  • 货号：
    CSB-BP021724RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc8a2重组蛋白
  • 货号：
    CSB-MP021724RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc8a2
  • Uniprot No.：
    P48768
  • 别名：
    Slc8a2; Ncx2; Sodium/calcium exchanger 2; Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
  • 基因功能参考文献：
    1. analyze the equilibrium and kinetic properties of Ca(2+) binding to purified preparations of CBD1, CBD2, and CBD12 from NCX2 and from NCX3 splice variants PMID: 26924806
    2. This study showed that normobaric hyperoxia changes the patterns of expression NCX2 in the penumbra and spinal cordcore. PMID: 23403180
    3. High levels of NCX2 overexpression increase neuronal survival following hypoxia-ischemia and improve neuronal calcium management. PMID: 22561287
    4. The presence of NCX2, together with multiple sodium channel isoforms, in free nerve endings may have important functional implications. PMID: 21118538
    5. Brain ischemia regulates gene expression levels of Na+/Ca2+ exchanger isoform NCX2, especially in cerebral cortex. PMID: 12377375
    6. NCX2 transcripts were expressed in the hippocampus, striatum, and paraventricular thalamic nucleus. NCX2 protein was expressed in the hippocampus, striatum, thalamus, and hypothalamus. PMID: 12722103
    7. Our main conclusion is that in rat cerebellar type 1 astrocytes under resting physiological conditions, most of the total transplasma membrane Ca2+ fluxes take place through the Na+/Ca2+ exchanger, thus accounting for the resting [Ca(2+)]i. PMID: 15541203

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily
  • 组织特异性：
    Detected in neocortex and hippocampus on pyramidal cells, astrocyte processes and dendrites (at protein level). Brain and skeletal muscle.
  • 数据库链接：

    KEGG: rno:140447

    STRING: 10116.ENSRNOP00000042012

    UniGene: Rn.10305

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