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  4. Recombinant Rat Serum albumin (Alb)

Recombinant Rat Serum albumin (Alb)

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  • 中文名称：
    Recombinant Rat Serum albumin(Alb)
  • 货号：
    CSB-EP001561RA
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Alb
  • Uniprot No.：
    P02770
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    75.2
  • 表达区域：
    25-608aa
  • 氨基酸序列
    EAHKSEIAHRFKDLGEQHFKGLVLIAFSQYLQKCPYEEHIKLVQEVTDFAKTCVADENAENCDKSIHTLFGDKLCAIPKLRDNYGELADCCAKQEPERNECFLQHKDDNPNLPPFQRPEAEAMCTSFQENPTSFLGHYLHEVARRHPYFYAPELLYYAEKYNEVLTQCCTESDKAACLTPKLDAVKEKALVAAVRQRMKCSSMQRFGERAFKAWAVARMSQRFPNAEFAEITKLATDVTKINKECCHGDLLECADDRAELAKYMCENQATISSKLQACCDKPVLQKSQCLAEIEHDNIPADLPSIAADFVEDKEVCKNYAEAKDVFLGTFLYEYSRRHPDYSVSLLLRLAKKYEATLEKCCAEGDPPACYGTVLAEFQPLVEEPKNLVKTNCELYEKLGEYGFQNAVLVRYTQKAPQVSTPTLVEAARNLGRVGTKCCTLPEAQRLPCVEDYLSAILNRLCVLHEKTPVSEKVTKCCSGSLVERRPCFSALTVDETYVPKEFKAETFTFHSDICTLPDKEKQIKKQTALAELVKHKPKATEDQLKTVMGDFAQFVDKCCKAADKDNCFATEGPNLVARSKEALA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged and C-terminal Avi-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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Alb antibodies

Alb Proteins

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靶点详情

  • 功能：
    Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
  • 基因功能参考文献：
    1. Tubular Expression and Urinary Excretion of MMP-9 Protein Were Increased in Association with Albumin Overload in the Diabetic Kidneys. PMID: 28805677
    2. albumin immunoreactivity was newly observed in microglia in the hippocampal CA1 region following 5 min of transient cerebral ischemia. These results indicate that transient ischemia-induced albumin expression in microglia might be associated with ischemia-induced 'delayed neuronal death' in the hippocampal CA1 pyramidal neurons. PMID: 28586018
    3. significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn PMID: 26887834
    4. Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 PMID: 26806786
    5. Megalin/cubilin and lysosome rupture is involved in albumin-triggered tubular injury and tubulointerstitial inflammation. PMID: 26025362
    6. Both insulin and high glucose concentrations enhance the permeability of podocytes to albumin by stimulating oxygen free radical production, primarily by NAD(P)H oxidase-4 (NOX4), and by activating protein kinase G, isoform Ialpha. PMID: 25888796
    7. Overall, rats with albumin deficiency display enhanced glucose tolerance, insulin secretion and gluconeogenic flux. PMID: 22198013
    8. albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase PMID: 22815976
    9. Data indicate that transcription of Alb is regulated by a complicated system of distant enhancers. PMID: 21858039
    10. This pioneering study determined a higher level of ischemia-modified albumin in a testicular torsion model. PMID: 20452583
    11. Forced expression of PPAR-gamma or C/EBP-alpha in activated pancreatic stellate cells induced albumin expression, thereby reverting cells to the quiescent phenotype. PMID: 19932685
    12. Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control PMID: 11983891
    13. This study suggests that Aroclor 1254 induces elevated albumin serum levels indirectly through induction of liver-enriched transcription factors, which regulate albumin gene expression PMID: 12051991
    14. an accelerated plasma efflux of albumin contributes to hypoalbuminemia only during the early period of sepsis PMID: 12571074
    15. albumin affects glucose metabolism by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism PMID: 12970360
    16. Kinetics of albumin production during rat liver development. PMID: 17879097

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    ALB/AFP/VDB family
  • 组织特异性：
    Plasma.
  • 数据库链接：

    KEGG: rno:24186

    STRING: 10116.ENSRNOP00000003921

    UniGene: Rn.202968

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