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  4. Recombinant Rat Rho guanine nucleotide exchange factor 11 (Arhgef11), partial

Recombinant Rat Rho guanine nucleotide exchange factor 11 (Arhgef11), partial

  • 中文名称：
    Recombinant Rat Rho guanine nucleotide exchange factor 11(Arhgef11) ,partial
  • 货号：
    CSB-YP887669RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Rho guanine nucleotide exchange factor 11(Arhgef11) ,partial
  • 货号：
    CSB-EP887669RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Rho guanine nucleotide exchange factor 11(Arhgef11) ,partial
  • 货号：
    CSB-EP887669RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Rho guanine nucleotide exchange factor 11(Arhgef11) ,partial
  • 货号：
    CSB-BP887669RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Rho guanine nucleotide exchange factor 11(Arhgef11) ,partial
  • 货号：
    CSB-MP887669RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Arhgef11
  • Uniprot No.：
    Q9ES67
  • 别名：
    Arhgef11Rho guanine nucleotide exchange factor 11; RhoGEF glutamate transport modulator GTRAP48
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
  • 基因功能参考文献：
    1. genetic variants in Arhgef11 via increased expression and/or protein activity play a role in promoting kidney injury in the Dahl salt-sensitive rat through changes in cell morphology (Rho-Rock and/or EMT) that impact the function of tubule cells PMID: 26172442
    2. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. PMID: 24106280
    3. Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Galpha(q/11)--p63RhoGEF--RhoA axis. PMID: 23696743
    4. Data show that Arhgef11 plays an important role in the activation of the Rho-ROCK signaling pathway. PMID: 22987919
    5. Data provide for the first time evidence that p63RhoGEF is an important mediator of ANG II-dependent RhoA activation in RASMCs and therewith a leading actor in the subsequently triggered cellular processes, such as proliferation and contraction. PMID: 20739613
    6. Acute ethanol exposure increases EAAT4 activity at clinically relevant concentrations and that PKC and PI3K may mediate this. PMID: 18226120

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  • 亚细胞定位：
    Cytoplasm. Membrane.
  • 数据库链接：

    KEGG: rno:78966

    STRING: 10116.ENSRNOP00000020717

    UniGene: Rn.229365

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