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  4. Recombinant Rat Proprotein convertase subtilisin/kexin type 5 (Pcsk5), partial

Recombinant Rat Proprotein convertase subtilisin/kexin type 5 (Pcsk5), partial

  • 中文名称：
    大鼠Pcsk5重组蛋白
  • 货号：
    CSB-YP017644RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Pcsk5重组蛋白
  • 货号：
    CSB-EP017644RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Pcsk5重组蛋白
  • 货号：
    CSB-EP017644RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Pcsk5重组蛋白
  • 货号：
    CSB-BP017644RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Pcsk5重组蛋白
  • 货号：
    CSB-MP017644RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pcsk5
  • Uniprot No.：
    P41413
  • 别名：
    Pcsk5; Proprotein convertase subtilisin/kexin type 5; EC 3.4.21.-; Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; Subtilisin/kexin-like protease PC5; rPC5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.
  • 基因功能参考文献：
    1. downregulation of Pcsk5 during cloaca development into the rectum and urethra might be related to the formation of anorectal malformations. PMID: 28975535
    2. Activation of alpha(v) integrin by proprotein convertase PC5 is necessary for integrin-mediated adhesion and migration by vascular smooth muscle cells (alpha(v) integrin). PMID: 14970114
    3. PCSK5A as the gonadotropin-regulated PCSK isoform in the ovary, and its possible contribution to ovulation PMID: 18502031
  • 亚细胞定位：
    [Isoform PC5A]: Secreted.; [Isoform PC5B]: Endomembrane system; Single-pass type I membrane protein.
  • 蛋白家族：
    Peptidase S8 family
  • 组织特异性：
    Expressed in the intestine, brain, adrenal gland, anterior pituitary, thyroid, ovaries, testis and lung. Highest levels are found in the gut, duodenum, jejunum and ileum. Expression is higher in female than in male reproductive organs.
  • 数据库链接：

    KEGG: rno:116548

    STRING: 10116.ENSRNOP00000016164

    UniGene: Rn.104002

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