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  4. Recombinant Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Hcn2), partial

Recombinant Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Hcn2), partial

  • 中文名称：
    大鼠Hcn2重组蛋白
  • 货号：
    CSB-YP881331RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Hcn2重组蛋白
  • 货号：
    CSB-EP881331RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Hcn2重组蛋白
  • 货号：
    CSB-EP881331RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Hcn2重组蛋白
  • 货号：
    CSB-BP881331RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Hcn2重组蛋白
  • 货号：
    CSB-MP881331RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hcn2
  • Uniprot No.：
    Q9JKA9
  • 别名：
    Hcn2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current.
  • 基因功能参考文献：
    1. Hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 protein expression levels were increased in the thalamus under chronic pain condition. Results suggest, increased HCN channel activity in the thalamus of the ascending nociceptive pathway contributes to both chronic neuropathic and inflammatory pain conditions. PMID: 27542339
    2. These results suggest that HCN2 in the subthalamic nucleus is involved in abnormal oscillation regulation between Motor cortex and globus pallidus . PMID: 25998542
    3. The results suggest that peripheral HCN2 channels contribute to mechanisms of spinal nerve injury-induced peripheral neuropathic pain. PMID: 25813712
    4. This study demonstrated that HCN2 contribute to heat hypersensitivity and ongoing activity in the neuritis model. PMID: 25290015
    5. Overexpression of HCN-2 channels in ventral tegmental area increases voluntary ethanol intake. PMID: 24460767
    6. Significant reductions in cardiac HCN2 mRNA and protein expression are demonstrated in genetic absence epilepsy rat-strain and acquired-epilepsy models. PMID: 24592881
    7. HCN2 channels contribute to inflammation-induced C-nociceptor hyperexcitability in chronic inflammatory pain. PMID: 22377439
    8. HCN2 band density in trigeminal ganglion neurons increased with postnatal age P1-P35. PMID: 21753027
    9. HCN2 is a basolateral ammonium transport pathway of intercalated cells and may contribute to the renal regulation of body pH under basal conditions. PMID: 21796099
    10. The results indicated that HCN2 ion channel mechanisms may play a role in SP-mediated spinal pain processing not only in naive animals but also in chronic inflammatory pain. PMID: 20726890
    11. HCN2 is distributed similarly to HCN1 along plasma membrane of dendritic shafts in layer I of the neocortex and stratum lacunosum moleculare of the hippocampal CA1 area. PMID: 14991560
    12. HCN2 widely co-localizes with calcitonin gene-related peptide, indicating HCN2 is expressed in peptidergic nociceptive primary afferents. Expression of HCN2 in terminals of peptidergic primary afferents was verified with electron microscopy. PMID: 15016091
    13. HCN2 staining was strongest in the MNTB and the dorsal nucleus of the lateral lemniscus. Strong HCN2 antibody labelling was also observed in bushy cells of the ventral cochlear nucleus. PMID: 15245481
    14. Mirpq channel acts as a beta subunit for HCN2 pacemaker channel subunits and alters channel gating at physiologically relevant voltages in cardiac cells. PMID: 15292247
    15. Consistent with the strong protein expression, an I(h) was recorded with features of an HCN2-mediated current in ST14A cells at the proliferative stage and in short-term-cultured E14 cells. PMID: 16175581
    16. expression levels of the HCN2 isoform found to be significantly higher in hypertrophied myocytes PMID: 16395601
    17. HCN-2 is the predominant subtype of HCN channels, which can control neuronal excitability, in small-sized C-fiber and medium-sized Adelta fiber DRG neurons including bladder afferent neurons. PMID: 16979600
    18. Reduction in HCN2 channel expression is an accompaniment of epileptogenesis in different adult models of temporal lobe epilepsy. PMID: 18397293
    19. HCN2 immunofluorescent staining was heterogeneous and predominantly in large diameter neurons and in small diameter IB4-negative neurons PMID: 18450385
    20. Overexpression of HCN2 channels blunts excitability of aortic baroreceptor neurons and baroreflex sensitivity in diabetic rats. PMID: 18524809
    21. Identify a four-amino acid motif (EEYP) in the B-helix of HCN2 that strongly promotes channel export from the endoplasmic reticulum and cell surface expression but does not contribute to the inhibition of channel opening. PMID: 18614814
    22. A loss of synchronous activity in the CA3 correlated with an increase in HCN2 mRNA levels that normalized concomitantly with the restoration of CA3 burst activity 7 days post insult. In PMID: 19500574

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel HCN family
  • 组织特异性：
    Highly expressed in neonatal and adult ventricle and in brain. Highly expressed in the pyramidal layer in hippocampus, in anterior dorsal nucleus in thalamus, in the mammillary nucleus in hypothalamus, in red nucleus, in trigeminal mesencephalic, spinal a
  • 数据库链接：

    KEGG: rno:114244

    STRING: 10116.ENSRNOP00000011837

    UniGene: Rn.162907

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