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  4. Recombinant Rat Plasma membrane calcium-transporting ATPase 1 (Atp2b1), partial

Recombinant Rat Plasma membrane calcium-transporting ATPase 1 (Atp2b1), partial

  • 中文名称：
    Recombinant Rat Plasma membrane calcium-transporting ATPase 1(Atp2b1) ,partial
  • 货号：
    CSB-YP002335RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Plasma membrane calcium-transporting ATPase 1(Atp2b1) ,partial
  • 货号：
    CSB-EP002335RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Plasma membrane calcium-transporting ATPase 1(Atp2b1) ,partial
  • 货号：
    CSB-EP002335RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Plasma membrane calcium-transporting ATPase 1(Atp2b1) ,partial
  • 货号：
    CSB-BP002335RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Plasma membrane calcium-transporting ATPase 1(Atp2b1) ,partial
  • 货号：
    CSB-MP002335RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp2b1
  • Uniprot No.：
    P11505
  • 别名：
    Atp2b1Plasma membrane calcium-transporting ATPase 1; EC 7.2.2.10; Plasma membrane calcium ATPase isoform 1; PMCA1; Plasma membrane calcium pump isoform 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts. Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells. May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
  • 基因功能参考文献：
    1. Negative calcium balance in aged ovariectomized female rats is associated with downregulation of PMCA1b. PMID: 24378673
    2. The contribution of PMCA after nerve injury in a rat model of neuropathic pain, is reported. PMID: 22713297
    3. VDR knockdown results in a decrease in [Ca(2)]i in NRK cell lines. * PMID: 20553254
    4. A Leu-Ile motif in 'b'-tail splice variants promotes PMCA1b and PMCA2b basolateral sorting in hair cells. PMID: 16803870
    5. Data suggest that PMCA1a is a calcium pump specialized for neurons, where it may contribute to the modulation of somatic and dendritic Ca(2+) transients. PMID: 20575074
    6. review mutagenesis work on the structure-function relationship of transmembrane segment M1 in the Na+,K+-ATPase and the sarco(endo)plasmic reticulum Ca2+-ATPase PMID: 18058007
    7. PMCA isoform 1b is released via aposomes of the epithelial cells of the rat coagulating gland and that the localization of PMCA1b in the epithelial cells is influenced by androgens PMID: 18395836
    8. Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance are reported. PMID: 19653992

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily
  • 组织特异性：
    Isoform B is ubiquitously expressed. Isoforms A and E have only been found in brain cortex. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small int
  • 数据库链接：

    KEGG: rno:29598

    STRING: 10116.ENSRNOP00000005491

    UniGene: Rn.228999

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