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  4. Recombinant Rat Peripheral plasma membrane protein CASK (Cask), partial

Recombinant Rat Peripheral plasma membrane protein CASK (Cask), partial

  • 中文名称：
    Recombinant Rat Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-YP723482RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-EP723482RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-EP723482RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-BP723482RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-MP723482RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cask
  • Uniprot No.：
    Q62915
  • 别名：
    Cask; Peripheral plasma membrane protein CASK; EC 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
  • 基因功能参考文献：
    1. induction of beta cell insulin-secretion defects by fatty acids is mediated, at least in part, by FOXO1 via downregulation of Cask expression PMID: 25796372
    2. The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane. PMID: 23542924
    3. Our study suggests that the stimulation of beta-cell insulin secretion by Ex-4 is mediated, at least in part, by CASK via a novel signaling mechanism. PMID: 24140090
    4. Depletion of liprin-alpha2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-alpha2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release. PMID: 23751498
    5. Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation. PMID: 19781660
    6. analysis of the nucleotide binding domain of CASK PMID: 12482754
    7. interacts with CIP98; co-localizes with CIP98 along the dendritic processes of neurons PMID: 12641734
    8. CASK and Dlg may act as a scaffold for organizing receptors and channels at the postsynaptic membrane of the neuromuscular junction. PMID: 15266631
    9. In conclusion, our study suggests that the CASK protein complex not only functions as a scaffold but also recruits signaling molecules and may contribute to signal transduction. PMID: 17084383
    10. Data show that Cask is present in the olfactory cilia. PMID: 18596612
    11. The function of calcium/calmodulin-dependent serine protein kinase (CASK), a MAGUK protein, in dendritic spine formation by RNA interference, is analyzed. PMID: 18606847
    12. The Tbr-1-CASK-CINAP complex regulates expression of NR2b;a Thr-to-Ala point mutation in CASK affects NR2b promoter activity. PMID: 19275891

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily; MAGUK family
  • 组织特异性：
    Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). Detected in brain and neurons.
  • 数据库链接：

    KEGG: rno:29647

    STRING: 10116.ENSRNOP00000004187

    UniGene: Rn.72627

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