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  4. Recombinant Rat Peptidyl-prolyl cis-trans isomerase F, mitochondrial (Ppif)

Recombinant Rat Peptidyl-prolyl cis-trans isomerase F, mitochondrial (Ppif)

  • 中文名称：
    大鼠Ppif重组蛋白
  • 货号：
    CSB-YP018476RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ppif重组蛋白
  • 货号：
    CSB-EP018476RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ppif重组蛋白
  • 货号：
    CSB-EP018476RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ppif重组蛋白
  • 货号：
    CSB-BP018476RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ppif重组蛋白
  • 货号：
    CSB-MP018476RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ppif
  • Uniprot No.：
    P29117
  • 别名：
    Ppif; Peptidyl-prolyl cis-trans isomerase F; mitochondrial; PPIase F; EC 5.2.1.8; Cyclophilin D; CyP-D; CypD; Cyclophilin F; Rotamase F
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-206
  • 氨基酸序列
    C SDGGARGANS SSQNPLVYLD VGADGQPLGR VVLELKADVV PKTAENFRAL CTGEKGFGYK GSTFHRVIPA FMCQAGDFTN HNGTGGKSIY GSRFPDENFT LKHVGPGVLS MANAGPNTNG SQFFICTIKT DWLDGKHVVF GHVKEGMDVV KKIESFGSKS GKTSKKIVIT DCGQLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
  • 基因功能参考文献：
    1. Knockdown of Cyclophilin D by RNAi protects kidney cell line from hypoxia-induced cell death. PMID: 20588055
    2. These results suggest a physiologic function for CypD and the mitochondrial permeability transition in the regulation of starvation-induced autophagy. PMID: 20364102
    3. Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy. PMID: 19094991
    4. Data show that CyP-D has a major pathogenic role in 'energy failure', but not in glutamate excitotoxicity. PMID: 19832699
    5. Together, these results indicate that Ca2+ overload in vivo and an altered expression of CypD could predispose mitochondria to permeability transition in denervated muscles. PMID: 16675492
    6. Together our data indicate that the increased calcium threshold of brain mitochondria to the MPT correlates with low expression of CypD in brain; and that neuronal cells lose CypD during differentiation and become less sensitive to the MPT induction. PMID: 16876914
    7. The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition.( PMID: 18667415
    8. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect PMID: 19228691
    9. The results from this study demonstrate that different levels of the mitochondrial matrix protein cypD exist within various brain regions and between different cell types. PMID: 18951528
    10. The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging. PMID: 19299432
    11. The present study examines the effects of cyclophilin-D on mitochondrial permeability transition and lethal cell injury. PMID: 15233627

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Cyclophilin-type PPIase family
  • 数据库链接：

    KEGG: rno:282819

    STRING: 10116.ENSRNOP00000014382

    UniGene: Rn.2923

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